嗜酸性粒细胞核糖核酸酶
The eosinophil ribonucleases.
作者信息
Rosenberg H F
机构信息
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
出版信息
Cell Mol Life Sci. 1998 Aug;54(8):795-803. doi: 10.1007/s000180050208.
Abstract
The eosinophil ribonucleases, eosinophilderived neurotoxin (EDN/RNase 2) and eosinophil cationic protein (ECP/RNase 3) are two closely related proteins with intriguing functional and evolutionary properties. While both EDN and ECP maintain the structural and catalytic residues typical of the RNase A superfamily, the role of ribonuclease activity in the physiologic function of these proteins remains unclear. The biochemistry and physiology of EDN, ECP and the recently discovered ribonuclease k6 (RNase 6) will be reviewed in this chapter.
摘要
嗜酸性粒细胞核糖核酸酶、嗜酸性粒细胞衍生神经毒素（EDN/RNase 2）和嗜酸性粒细胞阳离子蛋白（ECP/RNase 3）是两种密切相关的蛋白质，具有有趣的功能和进化特性。虽然EDN和ECP都保留了核糖核酸酶A超家族典型的结构和催化残基，但核糖核酸酶活性在这些蛋白质生理功能中的作用仍不清楚。本章将综述EDN、ECP以及最近发现的核糖核酸酶k6（RNase 6）的生物化学和生理学。
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