Oosaki R, Mizushima Y, Kawasaki A, Mita H, Akiyama K, Kobayashi M
First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.
Clin Exp Allergy. 1998 Sep;28(9):1138-44. doi: 10.1046/j.1365-2222.1998.00361.x.
Various kinds of cells and their mediators are thought to be involved in the pathogenesis of bronchial asthma. However, changes in each mediator or relationship among mediators during an asthmatic attack have not been well documented. In this study, to clarify whether eosinophil protein X (EPX) is a marker which is distinct from leukotriene E4 (LTE4), or 11-dehydrothromboxane B2 (11DTXB2), we measured the urinary excretion of EPX, LTE4, and 11DTXB2 in 14 asthmatics who were admitted to the hospital with either an acute asthmatic attack or status asthmaticus. These patients included eight atopic and six non-atopic types of bronchial asthma, with a median age of 34.0 years. Urinary excretion of EPX was significantly high on admission with the asthmatic attack, and returned to control levels 175 [122 -384] microg/day when the patients were in the improved state (1036-317 microg/day, P < 0.01). Similar findings were observed in LTE4 (155-59 ng/day, P < 0.01) and 11DTXB2 (991-442ng/day, P<0.01). No significant differences in values were observed between atopic and non-atopic types of asthma in all three substances. When the individual data during the attack state were analysed, a significant correlation was observed between changes (%) in urinary EPX and those in urinary LTE4, but no such relationship was observed between changes (%) in urinary EPX and those in urinary 11DTXB2. These results suggest that measuring urinary EPX levels may be a useful marker for the understanding and management of the disease.
人们认为多种细胞及其介质参与了支气管哮喘的发病机制。然而，在哮喘发作期间每种介质的变化或介质之间的关系尚未得到充分记录。在本研究中，为了阐明嗜酸性粒细胞蛋白X（EPX）是否是一种不同于白三烯E4（LTE4）或11-脱氢血栓素B2（11DTXB2）的标志物，我们测量了14例因急性哮喘发作或哮喘持续状态入院的哮喘患者尿液中EPX、LTE4和11DTXB2的排泄量。这些患者包括8例特应性和6例非特应性支气管哮喘患者，中位年龄为34.0岁。哮喘发作入院时，尿液中EPX的排泄量显著升高，当患者病情好转时恢复到对照水平175[122 - 384]μg/天（1036 - 317μg/天，P < 0.01）。LTE4（155 - 59 ng/天，P < 0.01）和11DTXB2（991 - 442 ng/天，P < 0.01）也观察到类似结果。在所有三种物质中，特应性和非特应性哮喘类型之间的值没有显著差异。当分析发作状态期间的个体数据时，观察到尿液中EPX变化（%）与尿液中LTE4变化（%）之间存在显著相关性，但尿液中EPX变化（%）与尿液中11DTXB2变化（%）之间未观察到这种关系。这些结果表明，测量尿液中EPX水平可能是理解和管理该疾病的有用标志物。
