Oosaki R, Mizushima Y, Kawasaki A, Kashii T, Mita H, Shida T, Akiyama K, Kobayashi M
First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.
Int Arch Allergy Immunol. 1997 Dec;114(4):373-8. doi: 10.1159/000237697.
Cysteinyl leukotrienes (LTs) and thromboxane A2 (TXA2) are known to play an essential role in the pathogenesis of atopic asthma. However, their role in nonatopic asthma has not as yet been clarified. The objectives of this study were to define (1) the participation of LTs and TXA2 in nonatopic asthma and (2) the relationship between LTs and TXA2 in asthma attacks.
Urinary excretion of leukotriene E4 (LTE4) and 11-dehydrothromboxane B2 (11DTXB2) was measured in 10 atopic and 10 nonatopic asthmatics who were admitted to hospital with either an acute asthma attack or status asthmaticus.
In atopic asthmatics, urinary excretion of LTE4 and 11DTXB2 was significantly higher on admission with an asthma attack, and returned to control levels when the patients were in the improved state (179+/-29 to 65+/-16 ng/day in LTE4, 1,085+/-250 to 440+/-90 ng/day in 11DTXB2). Similar findings were observed in nonatopic asthmatics (148+/-13 to 61+/-11 ng/day in LTE4, 1,089+/-206 to 457+/-60 ng/day in 11DTXB2). However, when the individual data during the attack were analyzed, there was no correlation between urinary excretion of LTE4 and that of 11DTXB2 in both types of asthma.
Both LTs and TXA2 may be implicated in the pathogenesis of the nonatopic as well as the atopic type of asthma, but no correlation between these two metabolites was observed in the individuals.
已知半胱氨酰白三烯（LTs）和血栓素A2（TXA2）在特应性哮喘的发病机制中起重要作用。然而，它们在非特应性哮喘中的作用尚未阐明。本研究的目的是确定（1）LTs和TXA2在非特应性哮喘中的参与情况，以及（2）哮喘发作时LTs和TXA2之间的关系。
对10名特应性哮喘患者和10名非特应性哮喘患者进行了研究，这些患者因急性哮喘发作或哮喘持续状态入院，测量了他们尿液中白三烯E4（LTE4）和11-脱氢血栓素B2（11DTXB2）的排泄量。
在特应性哮喘患者中，哮喘发作入院时尿液中LTE4和11DTXB2的排泄量显著升高，病情改善时恢复至对照水平（LTE4从179±29 ng/天降至65±16 ng/天，11DTXB2从1085±250 ng/天降至440±90 ng/天）。在非特应性哮喘患者中也观察到类似结果（LTE4从148±13 ng/天降至61±11 ng/天，11DTXB2从1089±206 ng/天降至457±60 ng/天）。然而，分析发作期间的个体数据时，两种类型的哮喘中LTE4和11DTXB2的尿液排泄量之间均无相关性。
LTs和TXA2可能均参与非特应性和特应性哮喘的发病机制，但个体中这两种代谢产物之间未观察到相关性。
