Robillard P Y, Dekker G A, Hulsey T C
Neonatology, Centre Hospitalier Territorial, Papeete, Tahiti, French Polynesia.
Aust N Z J Obstet Gynaecol. 1998 Aug;38(3):284-7. doi: 10.1111/j.1479-828x.1998.tb03067.x.
Pregnancy-induced hypertensive disorders (and especially preeclampsia) remain nowadays the major problem of human reproduction as it occurs in at least 10% of all world population births. It is a major cause of maternal-fetal mortality and morbidity in developed and developing countries. This disease was until recently classically considered as a disease of primigravidas with little recurrence in multigravidas. Nevertheless, recent evidences in the last half decade suggest that this disease is indeed a disease of first pregnancies, but at the level of a couple (primipaternity) rather than only the mother's side (primigravidity). Therefore, multigravidas share the risk with primigravidas in case of conception with a new partner. We expose the biological plausibility of this new approach (immunogenetic factors), and propose its epidemiological consequences with proposals of future research for health workers or demographers working at the level of populations. If pregnancy-induced disorders are disease of new couples, then their patterns are probably very different according to the broad reproductive patterns existing among different cultures (contraception, matrifocality or patrifocality, age at marriage, changes of reproductive partners et cetera).
妊娠高血压疾病（尤其是子痫前期）如今仍是人类生殖领域的主要问题，因为全球至少10%的分娩都受其影响。在发达国家和发展中国家，它都是孕产妇和胎儿发病及死亡的主要原因。直到最近，这种疾病一直被传统地认为是初产妇的疾病，经产妇很少复发。然而，过去五年的最新证据表明，这种疾病实际上是首次怀孕的疾病，但发生在夫妻层面（初父身份），而不仅仅是母亲一方（初孕）。因此，经产妇在与新伴侣受孕时与初产妇面临相同风险。我们阐述了这种新方法（免疫遗传因素）的生物学合理性，并提出其流行病学后果，同时为从事人群层面工作的卫生工作者或人口统计学家提供未来研究建议。如果妊娠相关疾病是新夫妻的疾病，那么根据不同文化中存在的广泛生殖模式（避孕、母系或父系中心、结婚年龄、生殖伴侣变化等），其模式可能会有很大差异。
