Van Erum R, Mulier G, Carels C, de Zegher F
Department of Orthodontics, University of Leuven, Belgium.
Horm Res. 1998 Sep;50(3):141-6. doi: 10.1159/000023262.
Short children born small for gestational age (SGA) may be candidates for treatment with growth hormone (GH). We examined craniofacial growth and dental maturation in a cohort of short SGA children. The general growth failure of these children is reflected to a differential extent within the craniofacial complex. As a group, these children have a small retrognathic face with a relatively increased lower anterior face height; in contrast to skeletal maturation, dental age is not delayed. GH treatment in short prepubertal SGA children leads to craniofacial catch-up growth, which is particularly pronounced in regions where interstitial cartilage is involved, the result being that the facial profile becomes less convex; dental maturation does not appear to be influenced by GH treatment. In conclusion, in short SGA children, GH treatment does not only result in an increase of body stature but also in a trend towards normalization of craniofacial growth and this without notable advancement of dental maturation.
出生时小于胎龄（SGA）的矮身材儿童可能是生长激素（GH）治疗的候选对象。我们研究了一组SGA矮身材儿童的颅面生长和牙齿成熟情况。这些儿童的整体生长发育迟缓在颅面复合体中表现出不同程度的差异。总体而言，这些儿童面部后缩，下颌前面部高度相对增加；与骨骼成熟不同，牙齿年龄并未延迟。青春期前SGA矮身材儿童接受GH治疗可导致颅面追赶生长，在涉及间质软骨的区域尤为明显，结果是面部轮廓的凸度减小；牙齿成熟似乎不受GH治疗的影响。总之，对于SGA矮身材儿童，GH治疗不仅能使身高增加，还能使颅面生长趋于正常化，且不会显著促进牙齿成熟。
