Kim Yesel, Lee Nam-Ki, Kim Jae Hyun, Ku Jeong-Kui, Lee Bu-Kyu, Jung Hoi-In, Choi Sun-Kyu
Department of Preventive Dentistry and Public Oral Health, Yonsei University, Seoul, Korea.
Department of Orthodontics, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam-si, Korea.
Maxillofac Plast Reconstr Surg. 2020 Aug 26;42(1):30. doi: 10.1186/s40902-020-00274-3. eCollection 2020 Dec.
Dental studies of precocious puberty have focused on examination of jaw and dentition growth. The aim of the study was to analyze the relationship between precocious puberty and maxillary dental developmental abnormalities (DDAs).
This retrospective study was conducted on the Korean patients in whom dental panoramic and hand-wrist radiographs had been taken before they were 15 years of age. The maxillary DDAs were assessed as mesiodens, congenital missing teeth, peg-shape lateral incisors, or impacted teeth. The chronological ages of the control group members were within the normal range of the hand-wrist bone age. Others with a peak luteinizing hormone of ≥ 5 and < 5 IU/L were allocated to central precocious puberty (CPP) and peripheral precocious puberty (PPP), respectively.
Of the enrolled 270 patients, 195, 52, and 23 were allocated to the control, CPP, and PPP groups, respectively. The maxillary DDAs were significantly more prevalent in the CPP group than in the other groups. Among those with maxillary DDA, the mesiodens predominated. Age- and sex-adjusted multivariate analysis revealed maxillary DDA (odds ratio, 3.36; 95% CI, 1.60-7.05) and especially mesiodens (odds ratio, 5.52; CI, 2.29-13.28) to be significantly associated with CPP.
Maxillary DDAs were significantly more prevalent in the CPP group than in the PPP or control groups. Among the many types of maxillary DDAs, mesiodens was significantly associated with CPP and may be considered a predictor of the development of CPP.
性早熟的牙科研究主要集中在颌骨和牙列生长的检查上。本研究的目的是分析性早熟与上颌牙齿发育异常（DDA）之间的关系。
本回顾性研究针对15岁之前拍摄过口腔全景片和手腕部X光片的韩国患者进行。上颌DDA被评估为正中多生牙、先天性缺牙、钉状侧切牙或阻生牙。对照组成员的实际年龄在手腕骨龄的正常范围内。促黄体生成素峰值≥5和<5 IU/L的其他患者分别被分配到中枢性性早熟（CPP）组和外周性性早熟（PPP）组。
在纳入的270例患者中，分别有195例、52例和23例被分配到对照组、CPP组和PPP组。上颌DDA在CPP组中的患病率显著高于其他组。在上颌DDA患者中，正中多生牙占主导。年龄和性别调整后的多变量分析显示，上颌DDA（优势比，3.36；95%可信区间，1.60 - 7.05），尤其是正中多生牙（优势比，5.52；可信区间，2.29 - 13.28）与CPP显著相关。
上颌DDA在CPP组中的患病率显著高于PPP组或对照组。在多种类型的上颌DDA中，正中多生牙与CPP显著相关，可被视为CPP发生的一个预测指标。
