Gullo L, Pezzilli R, Tomassetti P, de Giorgio R
Department of Internal Medicine and Gastroenterology, St. Orsola Hospital, University of Bologna, Italy.
Gastroenterol Clin Biol. 1998 Jan;22(1):25-8.
BACKGROUND/AIM: Ingestion of a meal causes the release of cholecystokinin and neurotensin into the circulation, but little is known about the duration of this release.
Six healthy volunteers were studied. Blood samples for cholecystokinin, neurotensin and gastrin assessment were drawn before and after consumption of a typical Italian lunch. Postprandial samples were obtained every hour for a total of 10 hours. All peptides were measured using previously validated radioimmunoassays.
Ingestion of the meal caused a prompt and significant increase in plasma levels of all three peptides. Cholecystokinin remained elevated for about 7 hours and then tended to return towards basal values, whereas the increase of neurotensin persisted for the entire period of the study (10 hours). Gastrin remained elevated for about 5 hours and then declined. The integrated CCK and gastrin responses during the initial postprandial hours were greater than those in the late hours, whereas the integrated neurotensin response during the initial hours was lower than that in the late hours.
The results indicate that, after an ordinary meal, cholecystokinin is released into the circulation for about 7 hours, much longer than previously reported (3-4 hours). The release of neurotensin begins soon after the meal and persists even longer, for at least 10 hours. Possible physiological implications of these findings are discussed.
背景/目的：进食一顿饭后会导致胆囊收缩素和神经降压素释放进入循环系统，但关于这种释放的持续时间知之甚少。
对6名健康志愿者进行了研究。在食用典型的意大利午餐前后采集血液样本，用于评估胆囊收缩素、神经降压素和胃泌素。餐后样本每小时采集一次，共采集10小时。所有肽类均使用先前验证过的放射免疫分析法进行测量。
进食该餐导致所有三种肽的血浆水平迅速且显著升高。胆囊收缩素在约7小时内保持升高，然后趋于恢复至基础值，而神经降压素的升高在整个研究期间（10小时）持续存在。胃泌素在约5小时内保持升高，然后下降。餐后最初几小时内胆囊收缩素和胃泌素的综合反应大于后期，而最初几小时内神经降压素的综合反应低于后期。
结果表明，普通餐后，胆囊收缩素释放进入循环系统约7小时，比先前报道的时间（3 - 4小时）长得多。神经降压素在进食后不久开始释放，持续时间更长，至少10小时。讨论了这些发现可能的生理意义。
