Yamaki K, Manabe T, Tamura K, Ando K, Tobe T, Kuwahara C, Fukui Y
First Department of Surgery, Faculty of Medicine, Kyoto University.
Arukoru Kenkyuto Yakubutsu Ison. 1990 Jun;25(3):180-92.
We investigated the time courses of the plasma ethanol, acetaldehyde, gastrin and cholecystokinin (CCK) levels after the ingestion of ethanol (1g/kg, 21.5%, whisky) in healthy male adult volunteers. The ethanol level reached a peak at 15 to 45 minutes after the ingestion and then decreased almost linearly. The acetaldehyde level of the group who became flushed after drinking (the F group) peaked earlier than that of the other group whose faces became only slightly flushed (the N group). The gastrin level increased significantly and remained elevated for about 3 hours. In three of the nine subjects, the CCK level increased 75 minutes after drinking. As a result, the absorption of the ingested ethanol is more rapid than 15 minutes, followed by a quick catabolism of the absorbed ethanol to acetaldehyde, but the catabolic action of acetaldehyde in the F group is later than that in the N group. The plasma gastrin level is certified to increase after the ingestion of ethanol and this is not mediated by acetaldehyde because the intra-venous infusion of acetaldehyde was not increased the plasma gastrin level in dogs. CCK which stimulate the pancreatic enzymes may be considered to have a possibility relating to the development of alcoholic acute pancreatitis but the ingestion of ethanol showed no increase of the plasma CCK level. But we cannot deny the possibility of the individual differences in the hormonal reaction in these experiments.
我们在健康成年男性志愿者中研究了摄入乙醇（1g/kg，21.5%，威士忌）后血浆乙醇、乙醛、胃泌素和胆囊收缩素（CCK）水平随时间的变化过程。乙醇水平在摄入后15至45分钟达到峰值，然后几乎呈线性下降。饮酒后脸红的组（F组）的乙醛水平峰值出现得比面部仅轻微发红的另一组（N组）更早。胃泌素水平显著升高并持续约3小时。在9名受试者中的3名中，CCK水平在饮酒75分钟后升高。结果，摄入的乙醇吸收速度快于15分钟，随后吸收的乙醇迅速分解为乙醛，但F组中乙醛的分解作用晚于N组。已证实摄入乙醇后血浆胃泌素水平会升高，且这并非由乙醛介导，因为静脉输注乙醛并未使犬的血浆胃泌素水平升高。刺激胰腺酶的CCK可能被认为与酒精性急性胰腺炎的发生有关，但摄入乙醇并未使血浆CCK水平升高。但在这些实验中我们不能排除激素反应存在个体差异的可能性。
