Aarli J A
Epilepsia. 1976 Sep;17(3):283-91. doi: 10.1111/j.1528-1157.1976.tb03407.x.
IgA concentrations were determined in saliva from epileptic patients taking phenytoin and in saliva from healthy controls, by single radial immunodiffusion technique. Mean salivary IgA in epileptic children was 7.23 mg/ml; in healthy children, 16.44 mg/ml. Corresponding values for adults were 13.53 and 19.48 mg/ml, respectively. In 14 out of 84 samples, salivary IgA levels were too low for quantitative analysis. Salivary IgA levels were normal in untreated patients and fell during treatment with phenytoin. Gingival inflammation was commonly accompanied by an increase of salivary IgG and serum-derived IgA, whereas compensatory increase of IgM was infrequent. Phenytoin-induced deficiency of salivary IgA can result in increased susceptibility to gingival inflammation, which is considered one of the predisposing factors for subsequent development of gingival hyperplasia.
采用单向辐射免疫扩散技术，测定了服用苯妥英钠的癫痫患者唾液和健康对照者唾液中的IgA浓度。癫痫儿童唾液中IgA的平均浓度为7.23毫克/毫升；健康儿童为16.44毫克/毫升。成人的相应值分别为13.53毫克/毫升和19.48毫克/毫升。在84份样本中的14份中，唾液IgA水平过低，无法进行定量分析。未经治疗的患者唾液IgA水平正常，而在苯妥英钠治疗期间下降。牙龈炎症通常伴随着唾液IgG和血清来源的IgA增加，而IgM的代偿性增加并不常见。苯妥英钠引起的唾液IgA缺乏会导致对牙龈炎症的易感性增加，这被认为是随后发生牙龈增生的诱发因素之一。
