Geuna S, Borrione P, Poncino A, Giacobini-Robecchi M G
Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, Italy.
Int J Dev Neurosci. 1998 Apr;16(2):85-95. doi: 10.1016/s0736-5748(98)00009-4.
The variations occurring in neurons from dorsal root ganglia that provide innervation to the regenerated tail of the lizard (vicarious ganglia) are analysed. Vicarious ganglion neurons, when compared to control ganglion neurons (i.e. ganglia from the same animal that were not involved in the reinnervation process), show a size increase of the soma (cell hypertrophy) which applies to all cell types and subtypes. No statistically significant differences in the relative percentage of neurofilament-poor (type D) and neurofilament-rich (type L) neurons were found between vicarious dorsal root ganglia compared to controls in all animals. On the contrary, within L neuron sub-types, a statistically significant increase in sub-type L2 (very rich in neurofilaments), and the appearance of sub-type L3 neuron which is not detectable in controls, were demonstrated in vicarious dorsal root ganglia. In spite of these variations in size and percentage distribution, no structural and ultrastructural differences of the various cell types and sub-types are detectable, except for the appearance of the sub-type L3 neurons. However, this neuron sub-type might not be considered specific of hypertrophy since the same morphological features have been observed, in normal conditions, in lizard dorsal root ganglia from cervical and lumbar spinal levels that provide innervation to limb plexuses.
对为蜥蜴再生尾巴提供神经支配的背根神经节（替代神经节）中的神经元变化进行了分析。与对照神经节神经元（即来自同一动物且未参与再支配过程的神经节）相比，替代神经节神经元的胞体大小增加（细胞肥大），这适用于所有细胞类型和亚型。在所有动物中，与对照相比，替代背根神经节中神经丝含量少的（D型）和神经丝含量丰富的（L型）神经元的相对百分比没有统计学上的显著差异。相反，在L神经元亚型中，替代背根神经节中L2亚型（神经丝非常丰富）有统计学上的显著增加，并且出现了对照中未检测到的L3亚型神经元。尽管在大小和百分比分布上存在这些变化，但除了L3亚型神经元的出现外，各种细胞类型和亚型在结构和超微结构上没有可检测到的差异。然而，这种神经元亚型可能不被认为是肥大所特有的，因为在正常情况下，在为肢体神经丛提供神经支配的颈段和腰段脊髓水平的蜥蜴背根神经节中也观察到了相同的形态特征。
