Tham S K, Morrison W A
Bernard O'Brien Institute of Microsurgery, Fitzroy, Victoria, Australia.
J Hand Surg Am. 1998 Sep;23(5):844-51. doi: 10.1016/S0363-5023(98)80161-5.
The outcome of end-to-side repair of peripheral nerves was investigated. The sciatic nerve in 10 male Sprague-Dawley rats was dissected to its tibioperoneal junction. The nerve to the medial gastrocnemius muscle, branching from the tibial nerve, was ligated at its origin and divided. Its distal end was sutured to an epineurial window on the side of the intact tibial nerve 1 cm distally. At 12 weeks, physiologic evaluation of the medial gastrocnemius muscle and analyses of histologic preparations of nerve and muscle were performed. The results showed that reinnervation successfully occurred in 8 rat media gastrocnemii. The mean weight of the reinnervated medial gastrocnemius was 73% of the contralateral normal muscle, the mean muscle fiber cross-sectional area of the reinnervated muscle was 72%, and the force of contraction was 60%. Analyses of histologic preparations revealed evidence of myelinated axons in the medial gastrocnemius nerve and no evidence of damage to axons of the donor tibial nerve.
对外周神经端侧修复的结果进行了研究。在10只雄性Sprague-Dawley大鼠中，将坐骨神经解剖至胫腓关节处。从胫神经分支至腓肠肌内侧头的神经在其起始处结扎并切断。其远端在完整胫神经一侧距其1 cm处缝合至神经外膜窗口。在12周时，对腓肠肌内侧头进行生理评估，并对神经和肌肉的组织学标本进行分析。结果显示，8只大鼠的腓肠肌内侧头成功实现了神经再支配。再支配的腓肠肌内侧头的平均重量为对侧正常肌肉的73%，再支配肌肉的平均肌纤维横截面积为72%，收缩力为60%。组织学标本分析显示，腓肠肌内侧头神经中有有髓轴突的证据，且供体胫神经的轴突没有损伤的证据。
