Kallmes D F, McGraw J K, Evans A J, Cloft H J, Mathis J M, Hergenrother R, Jensen M E, Dion J E
Department of Radiology, University of Virginia Health Sciences Center, Charlottesville 22908, USA.
Neuroradiology. 1998 Aug;40(8):530-5. doi: 10.1007/s002340050641.
We assessed the effect of systemic heparinization on the in-vivo thrombogenicity of various micro- and guiding catheters in a swine model. Microcatheters were placed through 6-F guiding catheters into the common carotid arteries of swine for 30-min (short-term) and 90-min (medium-term) periods, with and without systemic heparinization. At the end of the placement period the microcatheters were retracted through the guiding catheters and fixed for scanning electron microscopy (SEM). Guiding catheters were harvested after 5 h placement, with and without systemic heparinization, by retraction through 8-F sheaths and fixed for SEM. The surfaces of both hydrophilic and nonhydrophilic microcatheters all demonstrated more accumulation of debris during placement without than with systemic heparinization. The difference was primarily in the amount of fibrillary material on the catheter surface. The guiding catheters also demonstrated increased debris accumulation without systemic heparinization. This suggests that, even when using relatively nonthrombogenic catheters, systemic heparinization is indicated during cerebral angiography.
我们在猪模型中评估了全身肝素化对各种微导管和引导导管体内血栓形成性的影响。在有或没有全身肝素化的情况下，将微导管通过6F引导导管置入猪的颈总动脉30分钟（短期）和90分钟（中期）。在放置期结束时，将微导管通过引导导管撤回并固定用于扫描电子显微镜（SEM）检查。在有或没有全身肝素化的情况下，放置5小时后，通过8F鞘管撤回引导导管并固定用于SEM检查。与全身肝素化相比，在无肝素化的放置过程中，亲水性和非亲水性微导管表面均显示出更多的碎片堆积。差异主要在于导管表面纤维状物质的数量。引导导管在无全身肝素化时也显示出碎片堆积增加。这表明，即使使用相对不易形成血栓的导管，在脑血管造影期间也需要进行全身肝素化。
