大鼠上丘局部回路中的视觉运动通路。
The visuo-motor pathway in the local circuit of the rat superior colliculus.
作者信息
Isa T, Endo T, Saito Y
机构信息
Department of Integrative Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki 444-8585, Japan.
出版信息
J Neurosci. 1998 Oct 15;18(20):8496-504. doi: 10.1523/JNEUROSCI.18-20-08496.1998.
Intrinsic circuit of the superior colliculus (SC), in particular the pathway from the optic tract (OT) to neurons in the intermediate layer (SGI), was investigated by whole-cell patch-clamp recording in slice preparations obtained from 17- to 24-d-old rats. Stimulation of the OT induced monosynaptic EPSPs in neurons in the superficial gray layer (SGS) and the optic layer (SO), and disynaptic or polysynaptic EPSPs in a majority of SGI neurons. Stimulation of the SGS induced monosynaptic or oligosynaptic EPSPs in the SGI neurons. Both the monosynaptic EPSPs induced in the SGS/SO neurons by stimulation of the OT and those induced in the SGI neurons by stimulation of the SGS were mediated by AMPA- and NMDA-type glutamate receptors. Thus, we have clarified the existence of the glutamatergic excitatory pathway from the OT to the SGI neurons via SGS and SO neurons. The EPSPs in the SGI neurons induced by stimulation of the OT or SGS were remarkably enhanced by bicuculline, suggesting that the signal transmission in this pathway is under strong suppression by the GABAergic system.
利用全细胞膜片钳记录技术，对17至24日龄大鼠脑片标本中的上丘（SC）内在环路，特别是从视束（OT）到中间层（SGI）神经元的通路进行了研究。刺激OT可在浅灰层（SGS）和视层（SO）的神经元中诱发单突触兴奋性突触后电位（EPSP），并在大多数SGI神经元中诱发双突触或多突触EPSP。刺激SGS可在SGI神经元中诱发单突触或寡突触EPSP。由OT刺激在SGS/SO神经元中诱发的单突触EPSP以及由SGS刺激在SGI神经元中诱发的单突触EPSP均由AMPA型和NMDA型谷氨酸受体介导。因此，我们阐明了从OT经SGS和SO神经元到SGI神经元的谷氨酸能兴奋性通路的存在。由OT或SGS刺激在SGI神经元中诱发的EPSP被荷包牡丹碱显著增强，这表明该通路中的信号传递受到GABA能系统的强烈抑制。
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