Qingjun L, Jihui D, Laiyi T, Xiangjun Z, Jun L, Hay A, Shires S, Navaratnam V
Health and Epidemic Prevention Station, Changsha, Hunan, China.
Bull World Health Organ. 1998;76 Suppl 1(Suppl 1):21-7.
A study conducted in 1994 showed that the use of blister packs containing antimalarial drugs significantly increased patients' compliance, compared with traditional means of dispensing drugs in a paper envelope. The present study assessed patients' compliance and compared the difference between 3-day chloroquine and 8-day primaquine courses of treatment for vivax malaria. The level of real compliance was determined by making the drugs with phenobarbital, and measuring its level in the blood following treatment. The results show that blister packaging significantly improved patients' compliance (p < 0.001) over traditional means of dispensing antimalarial drugs; there was no difference in treatment compliance between 3-day and 8-day courses when the drugs were in blister packs. However, with ordinary packaging the treatment compliance rate for an 8-day course was significantly less than for a 3-day course (P < 0.05).
1994年进行的一项研究表明，与用纸质信封传统配药方式相比，使用含抗疟药物的泡罩包装显著提高了患者的依从性。本研究评估了患者的依从性，并比较了间日疟3天氯喹疗程和8天伯氨喹疗程之间的差异。通过在药物中加入苯巴比妥，并在治疗后测量其血液中的水平来确定实际依从性水平。结果显示，与传统抗疟药物配药方式相比，泡罩包装显著提高了患者的依从性（p<0.001）；当药物采用泡罩包装时，3天疗程和8天疗程的治疗依从性没有差异。然而，对于普通包装，8天疗程的治疗依从率显著低于3天疗程（P<0.05）。
