Molinari P F, Esber H J, Snyder L M
Exp Hematol. 1976 Sep;4(5):301-9.
Specific changes taking place in the erythroid tissue following depletion or replacement of androgens were studied in rats. The reduction of testosterone levels in blood of orchiectomized animals did occur in conjunction with a decline of erythrocyte glucose-6-phosphate (G6P) and lactate levels. No evidence of anemia was observed. The subcutaneous administration of testosterone propionate (16.0 mg/kg) to orchiectomized rats restored, within 12 hours, blood testosterone levels as well as erythrocyte G6P levels and lactate production. The in vitro incorporation of glucose-1-14C into rat erythrocytes incubated with testosterone was comparable to that of control cells. A radioautographic study of rat erythroid marrow pulsed with glucose-1-14C showed a lower labeling when testosterone propionate was administered. The authors conclude that testosterone does directly affect glucose metabolism of erythroid cells, via the pentose shunt pathway. The possible role of the androgen-dependent enhancement of erythroid glycolysis is discussed in relation to the function of testosterone receptocytes present in marrow cells and a 17beta-hydroxysteroid dehydrogenase present in erythrocytes.
在大鼠中研究了雄激素耗竭或替代后红系组织发生的特定变化。去势动物血液中睾酮水平的降低确实与红细胞葡萄糖-6-磷酸（G6P）和乳酸水平的下降同时发生。未观察到贫血迹象。给去势大鼠皮下注射丙酸睾酮（16.0 mg/kg），在12小时内恢复了血液睾酮水平以及红细胞G6P水平和乳酸生成。用睾酮孵育的大鼠红细胞中葡萄糖-1-¹⁴C的体外掺入量与对照细胞相当。对用葡萄糖-1-¹⁴C脉冲处理的大鼠红系骨髓进行放射自显影研究表明，给予丙酸睾酮时标记较低。作者得出结论，睾酮确实通过戊糖旁路途径直接影响红系细胞的葡萄糖代谢。讨论了雄激素依赖性增强红系糖酵解的可能作用与骨髓细胞中存在的睾酮受体细胞以及红细胞中存在的17β-羟基类固醇脱氢酶的功能的关系。
