Lider V A, Bogdanova S N
Biull Eksp Biol Med. 1986 Sep;102(9):283-5.
In experimental (white rats, rabbits) and clinical (erythrocytes, blood plasma) studies on 29 healthy subjects and patients it has been demonstrated that primary or secondary n-quinone deficiency is accompanied by increased tissue activity of glycolysis enzymes (aldolase, PGmutase) and aerobic pentose phosphate shunt (6 GPDH). Parallel rise in the amount of glycolysis metabolites (pyruvate and lactate) in the blood and the decline in blood plasma glucose level were observed. The changes in glucose-6-phosphate metabolism are, probably, secondary and reflect tissue structure alterations in the development of K and E avitaminosis.
在对29名健康受试者和患者进行的实验性（白鼠、兔子）及临床（红细胞、血浆）研究中已证实，原发性或继发性n-醌缺乏伴随着糖酵解酶（醛缩酶、磷酸葡萄糖变位酶）和有氧戊糖磷酸途径（6-磷酸葡萄糖脱氢酶）的组织活性增加。观察到血液中糖酵解代谢产物（丙酮酸和乳酸）含量平行上升以及血浆葡萄糖水平下降。6-磷酸葡萄糖代谢的变化可能是继发性的，反映了维生素K和维生素E缺乏症发展过程中的组织结构改变。
