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妊娠期间红细胞生成性原卟啉病病情改善。

Erythropoietic protoporphyria improving during pregnancy.

作者信息

Bewley A P, Keefe M, White J E

机构信息

Department of Dermatology, Royal South Hants Hospital, Southampton, U.K.

出版信息

Br J Dermatol. 1998 Jul;139(1):145-7. doi: 10.1046/j.1365-2133.1998.02333.x.

DOI:10.1046/j.1365-2133.1998.02333.x
PMID:9764168
Abstract

Erythropoietic protoporphyria is an uncommon disorder which causes a photosensitive cutaneous reaction, and occasionally hepatic dysfunction in affected individuals. We report a patient with erythropoietic protoporphyria who improved symptomatically during her two pregnancies. In the latter pregnancy, quantitative levels of plasma and erythrocyte protoporphyrins were reduced by more than half during the pregnancy compared with the levels before pregnancy and during lactation.

摘要

红细胞生成性原卟啉病是一种罕见的疾病,可导致光敏性皮肤反应,在受影响个体中偶尔还会引起肝功能障碍。我们报告了一名红细胞生成性原卟啉病患者,她在两次怀孕期间症状有所改善。在后一次怀孕期间,与怀孕前和哺乳期相比,血浆和红细胞原卟啉的定量水平在孕期降低了一半以上。

相似文献

1
Erythropoietic protoporphyria improving during pregnancy.妊娠期间红细胞生成性原卟啉病病情改善。
Br J Dermatol. 1998 Jul;139(1):145-7. doi: 10.1046/j.1365-2133.1998.02333.x.
2
Human protoporphyria: reduced cutaneous photosensitivity and lower erythrocyte porphyrin levels during pregnancy.人类原卟啉症:孕期皮肤光敏性降低及红细胞卟啉水平下降。
J Am Acad Dermatol. 1997 Jan;36(1):40-3. doi: 10.1016/s0190-9622(97)70323-2.
3
Burst-forming units-erythroid from erythropoietic protoporphyria patients fluoresce under 405 nm light.红细胞生成性原卟啉症患者的红系爆式集落形成单位在405纳米光线下会发出荧光。
Blood. 1996 May 15;87(10):4480-1.
4
Erythropoietic protoporphyria: altered phenotype after bone marrow transplantation for myelogenous leukemia in a patient heteroallelic for ferrochelatase gene mutations.
J Am Acad Dermatol. 2002 Jun;46(6):861-6. doi: 10.1067/mjd.2002.120460.
5
Erythropoietic protoporphyria, transfusion therapy and liver disease.红细胞生成性原卟啉症、输血治疗与肝脏疾病
Br J Dermatol. 1992 Nov;127(5):534-7. doi: 10.1111/j.1365-2133.1992.tb14855.x.
6
Cimetidine reduces erythrocyte protoporphyrin in erythropoietic protoporphyria.西咪替丁可降低红细胞生成性原卟啉症患者的红细胞原卟啉水平。
Am J Gastroenterol. 1993 Sep;88(9):1465-6.
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Delayed onset of cutaneous symptoms in erythropoietic protoporphyria.
Br J Dermatol. 2000 Jul;143(1):221-3. doi: 10.1046/j.1365-2133.2000.03637.x.
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Hemoglobin oxygen affinity is increased in erythropoietic protoporphyria.在红细胞生成性原卟啉症中,血红蛋白对氧的亲和力增加。
Photochem Photobiol. 1993 May;57(5):885-8. doi: 10.1111/j.1751-1097.1993.tb09229.x.
9
Transfusion medicine illustrated. Erythropoietic protoporphyria.《输血医学图解》。红细胞生成性原卟啉病。
Transfusion. 2004 Oct;44(10):1401. doi: 10.1111/j.1537-2995.2004.04058.x.
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Congenital erythropoietic protoporphyria in a Limousin calf.
J Am Vet Med Assoc. 2002 Jul 15;221(2):277-9, 240. doi: 10.2460/javma.2002.221.277.

引用本文的文献

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Evidence-based consensus guidelines for the diagnosis and management of erythropoietic protoporphyria and X-linked protoporphyria.基于证据的共识指南,用于诊断和管理红细胞生成性原卟啉症和 X 连锁原卟啉症。
J Am Acad Dermatol. 2023 Dec;89(6):1227-1237. doi: 10.1016/j.jaad.2022.08.036. Epub 2022 Aug 27.
2
Excess risk of adverse pregnancy outcomes in women with porphyria: a population-based cohort study.患有卟啉症的女性不良妊娠结局的风险增加:基于人群的队列研究。
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