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遗传性糖尿病前期小鼠的肾脏葡萄糖基转移酶活性升高。

Elevated kidney glucosyltransferase activity in genetic prediabetic mice.

作者信息

Reddi A S, Oppermann W, Reddy M P, Velasco C A, Camerini-Davalos R A

出版信息

Experientia. 1976 Oct 15;32(10):1237-8. doi: 10.1007/BF01953068.

DOI:10.1007/BF01953068
PMID:976428
Abstract

Glucosyltransferase activity in the renal cortex of genetic diabetic KK mice was significantly increased at 40 days of age when compared to that of Swiss albino and F1 hybrid mice. This increase in enzyme activity in the absence of glucose intolerance can be regarded as an earlier genetic marker for the diagnosis of diabetic microangiopathy.

摘要

与瑞士白化小鼠和F1杂种小鼠相比,遗传性糖尿病KK小鼠肾皮质中的葡萄糖基转移酶活性在40日龄时显著增加。在无葡萄糖不耐受情况下酶活性的这种增加可被视为诊断糖尿病微血管病变的一种早期遗传标志物。

相似文献

1
Elevated kidney glucosyltransferase activity in genetic prediabetic mice.遗传性糖尿病前期小鼠的肾脏葡萄糖基转移酶活性升高。
Experientia. 1976 Oct 15;32(10):1237-8. doi: 10.1007/BF01953068.
2
Renal glucosyltransferase activity in highly-inbred spontaneously diabetic Chinese hamsters.
Diabetologia. 1980 Jul;19(1):40-4. doi: 10.1007/BF00258309.
3
Effect of genetic diabetes on kidney glucosyltransferase.
Horm Metab Res. 1974 Sep;6(5):427. doi: 10.1055/s-0028-1095725.
4
Glucosyl transferase activity and diabetic microangiopathy.
Biomedicine. 1977 Apr;27(3):127-31.
5
Diabetic microangiopathy in KK mice. V. Effect of early glyburide treatment of kidney glucosyltransferase activity.
Exp Mol Pathol. 1978 Dec;29(3):442-7. doi: 10.1016/0014-4800(78)90084-9.
6
Effect of genetic diabetes on beta-N-acetylglucosaminidase activity in plasma, conjunctiva, muscle and kidney cortex of mice.
Biomedicine. 1981 Oct;35(5):159-61.
7
Diabetic microangiopathy in KK mice. IV. Effect of pyridinolcarbamate on kidney glucosyltransferase activity and glomerulosclerosis.
Exp Mol Pathol. 1978 Oct;29(2):149-55. doi: 10.1016/0014-4800(78)90035-7.
8
Renal glucose utilization in genetically diabetic microangiopathy.
Experientia. 1975 Oct 15;31(10):1130-2. doi: 10.1007/BF02326750.
9
[Proceedings: Use of the enzymatic determination of glycemia with the Dextrostix-Reflectance Meter in mass screening for diabetes mellitus].[会议论文:使用葡萄糖氧化酶法通过Dextrostix反射仪测定血糖在糖尿病大规模筛查中的应用]
Quad Sclavo Diagn. 1973 Mar;9(1):95-102.
10
Effect of several hormones on the tolerance to glucose in the non diabetic stage of KK mice.几种激素对KK小鼠非糖尿病阶段葡萄糖耐受性的影响。
J Exp Zool. 1969 Jun;171(2):209-15. doi: 10.1002/jez.1401710208.

引用本文的文献

1
Circulating blood and platelets supply glycosyltransferases that enable extrinsic extracellular glycosylation.循环血液和血小板提供糖基转移酶,这些酶能够实现外源性细胞外糖基化。
Glycobiology. 2017 Jan;27(2):188-198. doi: 10.1093/glycob/cww108. Epub 2016 Oct 26.
2
[Diabetic glomerulosclerosis: current status of its morphology and pathogenesis (author's transl)].糖尿病肾小球硬化症:其形态学与发病机制的现状(作者译)
Klin Wochenschr. 1980 Oct 1;58(19):1013-22. doi: 10.1007/BF01476871.
3
Renal glucosyltransferase activity in highly-inbred spontaneously diabetic Chinese hamsters.

本文引用的文献

1
Determination of serum proteins by means of the biuret reaction.通过双缩脲反应测定血清蛋白。
J Biol Chem. 1949 Feb;177(2):751-66.
2
Studies on the renal glomerular basement membrane. Preparation and chemical composition.肾小球基底膜的研究。制备及化学成分。
J Biol Chem. 1967 Apr 25;242(8):1915-22.
3
The chemistry of glomerular basement membrane and its relation to collagen.肾小球基底膜的化学性质及其与胶原蛋白的关系。
Diabetologia. 1980 Jul;19(1):40-4. doi: 10.1007/BF00258309.
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Studies of muscle capillary basement membranes in normal subjects, diabetic, and prediabetic patients.对正常受试者、糖尿病患者和糖尿病前期患者的肌肉毛细血管基底膜的研究。
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5
Studies of vascular and other lesions in KK mice.对KK小鼠血管及其他病变的研究。
Diabetologia. 1970 Jun;6(3):324-9. doi: 10.1007/BF01212246.
6
Platelet collagen adhesion characterization of collagen glucosyltransferase of plasma membranes of human blood platelets.人血小板质膜胶原葡萄糖基转移酶的血小板胶原黏附特性
Biochim Biophys Acta. 1971 Dec 21;252(3):533-45. doi: 10.1016/0304-4165(71)90156-5.
7
Effect of diabetes on the biosynthesis of the renal glomerular basement membrane. Studies on the glucosyltransferase.糖尿病对肾小球基底膜生物合成的影响。对葡萄糖基转移酶的研究。
Diabetes. 1971 Oct;20(10):641-8. doi: 10.2337/diab.20.10.641.
8
Excessive serum insulin response to oral glucose in obesity and mild diabetes. Study of 501 patients.肥胖症和轻度糖尿病患者口服葡萄糖后血清胰岛素反应过度。对501例患者的研究。
Diabetes. 1970 Jun;19(6):458-64. doi: 10.2337/diab.19.6.458.
9
KK mice as a model of microangiopathic lesions in diabetes.KK小鼠作为糖尿病微血管病变的模型。
Bibl Anat. 1973;11:453-8.
10
Biochemical and ultrastructural studies of conjunctiva of hereditary diabetic mice.遗传性糖尿病小鼠结膜的生化与超微结构研究。
Rev Eur Etud Clin Biol. 1972 Nov;17(9):882-6.