Madarame H, Itoh H, Yoshida S, Sakonju I, Takase K, Hasegawa Y
Laboratories of Experimental Animal Science, School of Veterinary Medicine and Animal Sciences, Aomori, Japan.
J Vet Med Sci. 1998 Aug;60(8):975-9. doi: 10.1292/jvms.60.975.
The tumor of the thoracic cavity, which arose from the ribs, was diagnosed as mesenchymal chondrosarcoma. No distant metastasis was observed. Histologically, the tumor was characterized by the nests of well-defined cartilaginous tissue within a proliferation of primitive mesenchymal cells. Additionally, the deformed blood vessels compressed by the proliferating mesenchymal cells exhibited clear stag-horn appearance. Immunohistochemically, most neoplastic cells that formed multifocal cartilaginous islands were positive for S-100 protein, while the surrounding mesenchymal cells were negative. This is the first report of canine mesenchymal chondrosarcoma of the ribs.
起源于肋骨的胸腔肿瘤被诊断为间叶性软骨肉瘤。未观察到远处转移。组织学上，肿瘤的特征是在原始间叶细胞增殖区内有界限清楚的软骨组织巢。此外，被增殖的间叶细胞挤压的变形血管呈现出清晰的鹿角状外观。免疫组织化学检查显示，形成多灶性软骨岛的大多数肿瘤细胞S-100蛋白呈阳性，而周围的间叶细胞呈阴性。这是犬肋骨间叶性软骨肉瘤的首例报道。
