Yildiz F, Gurel A, Yesildere T, Ozer K
Department of Pathology, Faculty of Veterinary Medicine, Istanbul University, Turkey.
J Vet Sci. 2003 Aug;4(2):193-4.
In this case, chondrosarcoma, detected on the frontal bone of a 12-year-old female cross-bred cat was examined clinically and histopathologically. After being processed routinely, specimens were stained with Hematoxylin & Eosin and Crossman Modification of Mallars Triple Stain. The neoplasm was composed of numerous fusiform mesenchymal cells intimately associated with the formation of lobular structure, separated by thin fibrous septae. In the center there were observed atypical chondrocytes, forming the matrix of the tumoral mass, surrounded by round-ovoid, fusiform mesenchymal cells having interference with the septal tissue at the periphery. Few mitotic figures were detected in these areas. The tumors pattern, localization, the species and the age of the animal were consistent with those of multilobular chondroma known as chondroma rodens. Although the mitotic figures and the wide atypia indicated that the entity was a neoplasm of malign type, it was more likely considered to be the malign transformation of chondroma rodens. The post-surgical outcome of the patient was observed, and recurrence on the same site was reported within 2 months.
在该病例中，对一只12岁雌性杂种猫额骨上检测到的软骨肉瘤进行了临床和组织病理学检查。标本经常规处理后，用苏木精和伊红染色以及马勒三色染色的克罗斯曼改良法染色。肿瘤由大量梭形间充质细胞组成，这些细胞与小叶结构的形成密切相关，被薄的纤维间隔分隔。在中央观察到非典型软骨细胞，形成肿瘤块的基质，周围是圆形 - 椭圆形、梭形间充质细胞，它们与周边的间隔组织相互交织。在这些区域检测到少量有丝分裂象。肿瘤的形态、定位、动物的种类和年龄与称为软骨瘤性软骨瘤的多叶状软骨瘤一致。尽管有丝分裂象和广泛的异型性表明该实体是恶性肿瘤类型，但更有可能被认为是软骨瘤性软骨瘤的恶性转化。观察了患者的术后结果，报告在2个月内在同一部位复发。
