Mutirangura A, Sriuranpong V, Termrunggraunglert W, Tresukosol D, Lertsaguansinchai P, Voravud N, Niruthisard S
Department of Anatomy, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Br J Cancer. 1998 Oct;78(7):933-9. doi: 10.1038/bjc.1998.604.
The purpose of this study was to define a correlation between telomerase activity and human papillomavirus (HPV) in normal control tissue and in benign, premalignant and malignant cervical lesions. Telomerase activity was detectable in 33 out of 34 cases of squamous-cell carcinoma, five out of six cases of microinvasive carcinoma, 8 out of 20 cases and two out of six cases of high- and low-grade squamous intraepithelial lesions (SILs) respectively. The higher frequency of positive telomerase in invasive carcinoma compared with SILs was observed in both HPV-associated and non-associated groups. Whereas 92.6% of HPV-positive and 100% of HPV-negative invasive lesions expressed telomerase, only 50% of HPV-positive and 25% of HPV-negative SILs did. Interestingly, telomerase activity was also detectable in 13 out of 28 cases of benign lesions regardless of the presence of HPV. In conclusion, there may be two roles of telomerase in the cervix. The first one would present in benign lesions; the second is associated with cancer development and activated during the late stage of multistep carcinogenesis in both HPV-positive and -negative groups.
本研究的目的是确定端粒酶活性与正常对照组织以及良性、癌前和恶性宫颈病变中的人乳头瘤病毒（HPV）之间的相关性。在34例鳞状细胞癌中的33例、6例微浸润癌中的5例、20例高级别和低级别鳞状上皮内病变（SIL）中的8例以及6例中的2例中分别检测到端粒酶活性。在HPV相关和非相关组中，均观察到浸润癌中端粒酶阳性频率高于SIL。92.6%的HPV阳性和100%的HPV阴性浸润性病变表达端粒酶，而HPV阳性SIL中只有50%，HPV阴性SIL中只有25%表达端粒酶。有趣的是，无论HPV是否存在，28例良性病变中的13例也可检测到端粒酶活性。总之，端粒酶在宫颈中可能有两种作用。第一种作用存在于良性病变中；第二种作用与癌症发展相关，并在HPV阳性和阴性组的多步骤致癌作用晚期被激活。
