Di Bona D, Montalto G, Clemenza L, Bascone F, Accardo P, Bellavia D, Craxì A, Brai M
Cattedra di Immunologia, Istituto di Patologia Generale, Palermo, Italy.
Clin Exp Immunol. 1998 Oct;114(1):102-5. doi: 10.1046/j.1365-2249.1998.00707.x.
Complement receptor type 1 (CR1) is an integral membrane protein of many haematopoietic cells and plays an important role in the clearance of complement-associated immune complexes, favouring their transport to liver and spleen macrophages. A small amount of soluble CR1 (sCR1) is also found in plasma and might originate directly from release of leucocytes and other circulating cells. In previous studies, an increase in serum sCR1 level has been observed in liver cirrhosis and end-stage renal failure. High levels have also been found in patients with some haematologic malignancies. sCR1 serum levels were measured using a specific double sandwich ELISA assay. The present study demonstrates the correlation between mean serum sCR1 concentrations and disease severity in patients with chronic liver disease. In patients with liver cirrhosis, grouped according to the Child-Pugh classification, sCR1 rose as liver function decreased. The presence of neoplastic growth in the liver apparently does not play a role in the increase of sCR1. Serum sCR1 was not elevated in other solid malignancies. Since sCR1 accumulates in liver diseases, evaluation of its serum levels could be useful as a liver function test.
1型补体受体（CR1）是许多造血细胞的一种整合膜蛋白，在补体相关免疫复合物的清除中起重要作用，有助于将其转运至肝脏和脾脏巨噬细胞。血浆中也发现少量可溶性CR1（sCR1），可能直接来源于白细胞和其他循环细胞的释放。在先前的研究中，肝硬化和终末期肾衰竭患者血清sCR1水平升高。一些血液系统恶性肿瘤患者中也发现sCR1水平较高。采用特异性双夹心ELISA法检测血清sCR1水平。本研究证实了慢性肝病患者血清sCR1平均浓度与疾病严重程度之间的相关性。在根据Child-Pugh分类法分组的肝硬化患者中，sCR1水平随肝功能下降而升高。肝脏中肿瘤生长的存在显然对sCR1的升高没有作用。其他实体恶性肿瘤患者血清sCR1未升高。由于sCR1在肝脏疾病中蓄积，评估其血清水平可能有助于肝功能检测。
