血清CA 125与早期流产

Serum CA 125 and first trimester abortion.

作者信息

Scarpellini F, Mastrone M, Sbracia M, Scarpellini L

机构信息

II Department of Obstetrics and Gynecology, University of Rome La Sapienza, Italy.

出版信息

Int J Gynaecol Obstet. 1995 Jun;49(3):259-64. doi: 10.1016/0020-7292(95)02371-i.

DOI:10.1016/0020-7292(95)02371-i

PMID:9764863

Abstract

OBJECTIVE

The study was carried out to assess the clinical value of serum CA 125 in association with serum beta-human chorionic gonadotropin (hCG) for predicting pregnancy outcome.

METHODS

One hundred spontaneous pregnancies, 52 non-threatened pregnancies and 48 with threatened abortions, observed in the Department of Obstetrics and Gynecology at the University 'La Sapienza', Rome, Italy, were evaluated during the first trimester using ultrasound examination, CA 125 and beta-hCG titrations.

RESULTS

Threatened pregnancies had statistically significantly higher CA 125 serum values than non-threatened pregnancies, especially those with a negative outcome (P < 0.01). The CA 125 levels in the threatened pregnancies were positively correlated with the tropho-decidual hematoma volume (r=0.839, P < 0.0001). The CA 125-beta-hCG association showed a higher prognostic value (sensitivity 78.9%, specificity 96.5%) in assessing pregnancy outcome than CA 125 or 0-hCG alone (sensitivity 78.9% and 57.9%, respectively; specificity 75.8% and 86.2%, respectively).

CONCLUSIONS

Our findings are in accordance with the hypothesis of a tropho-decidual origin of this marker, suggesting its possible usefulness in the prognostic evaluation of first trimester threatened abortion.

摘要

目的

本研究旨在评估血清CA 125联合血清β-人绒毛膜促性腺激素（hCG）预测妊娠结局的临床价值。

方法

在意大利罗马“La Sapienza”大学妇产科观察的100例自然妊娠、52例非先兆流产妊娠和48例先兆流产妊娠，在孕早期采用超声检查、CA 125和β-hCG滴定法进行评估。

结果

先兆流产妊娠的血清CA 125值在统计学上显著高于非先兆流产妊娠，尤其是那些结局不良的妊娠（P < 0.01）。先兆流产妊娠的CA 125水平与滋养层-蜕膜血肿体积呈正相关（r = 0.839，P < 0.0001）。在评估妊娠结局方面，CA 125-β-hCG联合检测显示出比单独检测CA 125或β-hCG更高的预后价值（敏感性78.9%，特异性96.5%）（单独检测CA 125和β-hCG的敏感性分别为78.9%和57.9%；特异性分别为75.8%和86.2%）。