Mazhitova Z, Jensen S, Ritzén M, Zetterström R
Children's Rehabilitation Center URPAK, Almaty, Kazakhstan.
Acta Paediatr. 1998 Sep;87(9):991-5. doi: 10.1080/080352598750031671.
It has been shown by others that offspring of mothers who had been exposed to dioxins and polychlorinated biphenyls (PCBs) during pregnancy have elevated plasma levels of thyroid-stimulating hormone (TSH) for at least 3 months after birth and reduced plasma levels of free and total thyroxine during the second week after birth. As elevated levels of dioxins and PCB s can thus alter thyroid hormone status, the relation between the levels of some polychlorinated organic compounds in the blood lipids and growth and thyroid hormone status was studied in 12 hospitalized schoolchildren from the Aral Sea region known to have high exposure to such compounds. Their level of PCBs was two to four times higher than in healthy Stockholm children. Their height was found to be lower than in healthy Swedish children of the same age mean (SDS -0.52) and the body mass index (BMI) was inversely correlated to the total concentrations of PCBs and dichlorodiphenyltrichloroethane (DDT) and its metabolite dichlorophenyldichloroethylene (DDE) in the blood lipids. As the levels of insulin-like growth factor- were reduced to the same extent as the BMI it seems likely that PCBs and DDT cause malnutrition as a result of malabsorption. None of the children had any impairment of thyroid function, as revealed by the plasma levels of TSH and thyroxine. Although the concentrations of beta-hexachlorocyclohexane (beta-HCH) and DDE were extremely high in some of the children there was no relation between thyroid hormone status and the blood lipid levels of PCBs, hexachlorocyclohexane and DDT. However, the concentration of dioxins was not analysed.
其他人的研究表明，孕期接触二恶英和多氯联苯（PCBs）的母亲所生的后代，出生后至少3个月促甲状腺激素（TSH）血浆水平升高，出生后第二周游离甲状腺素和总甲状腺素血浆水平降低。由于二恶英和多氯联苯水平升高会改变甲状腺激素状态，因此对已知高度接触此类化合物的咸海地区12名住院学童的血脂中某些多氯有机化合物水平与生长及甲状腺激素状态之间的关系进行了研究。他们的多氯联苯水平比健康的斯德哥尔摩儿童高两到四倍。发现他们的身高低于同龄健康瑞典儿童的平均身高（标准差 -0.52），且体重指数（BMI）与血脂中多氯联苯、二氯二苯三氯乙烷（DDT）及其代谢物二氯二苯二氯乙烯（DDE）的总浓度呈负相关。由于胰岛素样生长因子水平与BMI降低程度相同，似乎多氯联苯和滴滴涕由于吸收不良导致营养不良。血浆TSH和甲状腺素水平显示，这些儿童均无甲状腺功能损害。尽管一些儿童的β-六氯环己烷（β-HCH）和DDE浓度极高，但甲状腺激素状态与血脂中多氯联苯、六氯环己烷和滴滴涕水平之间没有关系。然而，未对二恶英浓度进行分析。
