Ollila P, Niemelä M, Uhari M, Larmas M
Department of Preventive Dentistry and Cariology, Institute of Dentistry, University of Oulu, Finland.
Acta Odontol Scand. 1998 Aug;56(4):233-7. doi: 10.1080/00016359850142853.
At the baseline of this cohort study we determined risk factors for colonization of oral lactobacilli and candida in a group of children (n = 166) whose mean age was 2.5 years. The results showed that pacifier-sucking and the use of a nursing bottle at night increase the occurrence of both salivary lactobacilli and candida. In the present study these children were followed for 2 years, and the progression of caries was recorded with particular reference to the etiologic factors measured before. The results of the logistic regression analysis showed prolonged pacifier-sucking (> or = 24 months) to be a significant risk factor for caries development in children, with a rather high relative risk (RR) of 3.5 (95% confidence interval (CI), 1.5-8.2; P= 0.003). Prolonged use of a nursing bottle at night (> or = 24 months) was also a risk factor, but less significant than pacifier-sucking (RR, 2.6; CI, 1.1-6.4; P= 0.03). On the grounds of this study we conclude that prolonged pacifier-sucking (> or = 2 years) and use of a nursing bottle at night are risk factors for dental caries in children.
在这项队列研究的基线阶段，我们在一组平均年龄为2.5岁的儿童（n = 166）中确定了口腔乳酸杆菌和念珠菌定植的风险因素。结果显示，使用安抚奶嘴和夜间使用奶瓶会增加唾液乳酸杆菌和念珠菌的发生率。在本研究中，对这些儿童进行了2年的随访，并特别参照之前测量的病因因素记录龋齿的进展情况。逻辑回归分析结果显示，长时间使用安抚奶嘴（≥24个月）是儿童龋齿发展的一个重要风险因素，相对风险（RR）相当高，为3.5（95%置信区间（CI），1.5 - 8.2；P = 0.003）。夜间长时间使用奶瓶（≥24个月）也是一个风险因素，但不如使用安抚奶嘴那么显著（RR，2.6；CI，1.1 - 6.4；P = 0.03）。基于本研究，我们得出结论，长时间使用安抚奶嘴（≥2年）和夜间使用奶瓶是儿童龋齿的风险因素。
