γ干扰素缺陷的C57BL/6小鼠中，鼠冠状病毒诱导的亚急性致命性腹膜炎
Murine coronavirus-induced subacute fatal peritonitis in C57BL/6 mice deficient in gamma interferon.
作者信息
Kyuwa S, Tagawa Y, Shibata S, Doi K, Machii K, Iwakura Y
机构信息
Department of Animal Pathology, Institute of Medical Science, University of Tokyo, Tokyo 108, Japan.
出版信息
J Virol. 1998 Nov;72(11):9286-90. doi: 10.1128/JVI.72.11.9286-9290.1998.
Abstract
Gamma interferon-deficient (IFN-gamma-/-) mice with a C57BL/6 background were infected intraperitoneally with mouse hepatitis virus strain JHM (JHMV). In contrast to IFN-gamma-+/- and IFN-gamma+/+ mice, JHMV persisted in IFN-gamma-/- mice and induced death during the subacute phase of the infection. Unexpectedly, infected IFN-gamma-/- mice showed severe peritonitis accompanying the accumulation of a viscous fluid in the abdominal and thoracic cavities in the subacute phase. Destructive changes of hepatocytes were not observed. Administration of recombinant IFN-gamma protracted the survival time of IFN-gamma-/- mice after JHMV infection. These results demonstrate that IFN-gamma plays a critical role in viral clearance in JHMV infection. They also show that a resultant persistent JHMV infection induces another form of disease in IFN-gamma-/- mice, which bears a resemblance to feline infectious peritonitis in cats.
摘要
背景为C57BL/6的γ干扰素缺陷（IFN-γ-/-）小鼠经腹腔感染小鼠肝炎病毒JHM株（JHMV）。与IFN-γ+/-和IFN-γ+/+小鼠不同，JHMV在IFN-γ-/-小鼠中持续存在，并在感染的亚急性期导致死亡。出乎意料的是，感染的IFN-γ-/-小鼠在亚急性期出现严重的腹膜炎，伴有腹腔和胸腔内粘性液体的积聚。未观察到肝细胞的破坏性变化。给予重组IFN-γ可延长JHMV感染后IFN-γ-/-小鼠的存活时间。这些结果表明，IFN-γ在JHMV感染的病毒清除中起关键作用。它们还表明，由此产生的持续性JHMV感染在IFN-γ-/-小鼠中诱发了另一种形式的疾病，这与猫的猫传染性腹膜炎相似。
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