[吸收紫外线的物质对枯草芽孢杆菌抗自然阳光灭活及诱变作用的影响]
[Effect of substances, absorbing ultraviolet irradiation on Bacillus subtilis resistance to inactivation and mutagenic action of natural sunlight].
作者信息
Lotareva O V, Filippov B D
机构信息
N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow.
出版信息
Radiats Biol Radioecol. 1998 Jul-Aug;38(4):595-600.
Substances, absorbing UV-irradiation from sunlight (triptophan, cistein, catalase) decrease Bacillus subtilis resistance to sunlight-induced lethal and mutagenic damages. Possible, they act as exogenous photosensitizers. Tryptophan was found to be the most active photosensitizer. Cistein and catalase are not so active. Casaminoacids being present in the bacterial suspensions during illumination protect bacteria from mutagenic action sunlight. In this studies we can demonstrate, that sunlight damage B. subtilis membranes and allows substances to penetration into cells. Following, that polishing of the environmental by chemical agents can strength genetic risk for organisms permanently exposure to sunlight.
能够吸收太阳光紫外线辐射的物质（色氨酸、胱氨酸、过氧化氢酶）会降低枯草芽孢杆菌对阳光诱导的致死性和致突变性损伤的抵抗力。它们可能作为外源性光敏剂发挥作用。已发现色氨酸是最具活性的光敏剂。胱氨酸和过氧化氢酶的活性则没那么高。光照期间细菌悬浮液中存在的酪蛋白氨基酸可保护细菌免受阳光的致突变作用。在本研究中我们可以证明，阳光会损伤枯草芽孢杆菌的细胞膜，并使物质能够进入细胞。接下来，通过化学试剂净化环境可能会增加生物体长期暴露于阳光下的遗传风险。
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