Materlik B, Steidle-Katic U, Wauschkuhn B, Feyerabend T, Richter E
Klinik für Strahlentherapie und Nuklearmedizin, Medizinischen Universität zu Lübeck.
Strahlenther Onkol. 1998 Sep;174(9):478-81. doi: 10.1007/BF03038627.
Extracranial metastases of malignant gliomas are rare. We report 2 cases with spinal metastases in patients suffering from glioma.
Two patients (33 and 57 years old) developed spinal canal metastases of a glioblastoma multiforme and anaplastic astrocytoma Grade III respectively 25 and 9 months after surgical resection and radiotherapy. Both metastases were confirmed pathohistologically.
Intraspinal metastases were irradiated with a total dose of 12.6 Gy and 50 Gy. Treatment withdrawal was necessary in one patient due to reduced clinical condition. Regression of neurological symptoms was observed in the second patient.
Spinal spread of malignant glioma should be considered during care and follow-up in glioma patients with spinal symptoms.
恶性胶质瘤的颅外转移罕见。我们报告2例患有胶质瘤的患者发生脊柱转移。
两名患者（分别为33岁和57岁）在手术切除和放疗后25个月和9个月分别发生了多形性胶质母细胞瘤和间变性星形细胞瘤Ⅲ级的椎管转移。两处转移均经病理组织学证实。
脊髓内转移灶分别接受了总剂量为12.6 Gy和50 Gy的照射。一名患者因临床状况恶化而不得不停止治疗。第二名患者的神经症状有所缓解。
对于有脊柱症状的胶质瘤患者，在护理和随访过程中应考虑恶性胶质瘤的脊柱播散。
