Ikeda M, Yu D T
Rheumatology Division, UCLA School of Medicine, Los Angeles, California, USA.
Am J Med Sci. 1998 Oct;316(4):257-63. doi: 10.1097/00000441-199810000-00006.
The way in which a host accommodates invasive facultative intracellular bacteria must be the key to the development of reactive arthritis. Investigators have analyzed the bacterial events at several levels: invasion into host cells, intracellular survival, translocation from the sites of infection to the joints, residence in the joints, and evasion of host defense. Because HLA-B27 is present in higher incidence in patients with reactive arthritis and is an essential gene in the related ankylosing spondylitis, the role of HLA-B27 in host defense is also assumed to be important in the development of reactive arthritis. This review summarizes the various studies in this field.
宿主容纳侵袭性兼性胞内细菌的方式必定是反应性关节炎发病的关键所在。研究人员已在多个层面分析了细菌相关事件：侵入宿主细胞、细胞内存活、从感染部位转移至关节、在关节内留存以及逃避宿主防御。由于反应性关节炎患者中HLA - B27的发病率较高，且其是相关强直性脊柱炎中的一个关键基因，因此HLA - B27在宿主防御中的作用在反应性关节炎发病过程中也被认为很重要。本综述总结了该领域的各项研究。
