Bravetti P, Membre H, Marchal L, Jankowski R
Department of Oral Pathology and Surgery, School of Dentistry, Henri Poincaré University, Nancy, France.
J Oral Maxillofac Surg. 1998 Oct;56(10):1170-6; discussion 1177. doi: 10.1016/s0278-2391(98)90765-0.
Previous studies have reported on the morphologic aspects of bone regeneration after maxillary sinus grafting. However, no previous studies have examinated the morphology of the maxillary sinus mucosa after grafting. The purpose of this study was to evaluate the histologic changes in the lining membrane after sinus augmentation.
A unilateral osteotomy of the lateral maxillary wall, medial displacement of the bony segments, and elevation of the sinus mucosa were performed in 12 goats. An autogenous bone graft combined with coralline particles was placed on the floor of the sinus in three animals, and coralline particles alone were placed in three other goats. Six goats were not grafted and were used as controls. Samples were harvested at 2.5, 4.5, and 6.5 months. The maxillary sinus mucosa was examined using light microscopy and scanning and transmission electronic microscopy.
The coralline particles were surrounded by fibrous connective tissue when used alone. The addition of iliac crest bone to the coralline particles stimulated bone formation. After the sinus augmentation, the mucosal lining showed a lack of glands in the lamina propria, and the epithelium showed an increase in goblet cells.
It was concluded that the sinus mucosa undergoes physiologic adaptations and remains healthy and free of chronic sinusitis after maxillary sinus grafting.
以往研究报道了上颌窦植骨后骨再生的形态学方面。然而，此前尚无研究检查植骨后上颌窦黏膜的形态。本研究的目的是评估上颌窦增高术后衬里膜的组织学变化。
对12只山羊进行上颌窦外侧壁单侧截骨、骨段向内移位以及窦黏膜提升。3只动物在窦底植入自体骨移植物联合珊瑚颗粒，另外3只山羊仅植入珊瑚颗粒。6只山羊不进行植骨作为对照。在2.5、4.5和6.5个月时采集样本。用上光显微镜以及扫描和透射电子显微镜检查上颌窦黏膜。
单独使用时，珊瑚颗粒被纤维结缔组织包围。在珊瑚颗粒中添加髂嵴骨可刺激骨形成。上颌窦增高术后，黏膜衬里在固有层显示腺体缺失，上皮显示杯状细胞增多。
得出的结论是，上颌窦植骨后，窦黏膜会发生生理适应性变化，保持健康且无慢性鼻窦炎。
