Department of Oral and Maxillofacial Surgery, Aalborg Hospital, Aarhus University Hospital, Aarhus, Denmark.
Clin Oral Implants Res. 2012 Aug;23(8):902-10. doi: 10.1111/j.1600-0501.2011.02245.x. Epub 2011 Nov 2.
The objective of the present study was to learn about the volumetric changes of the graft after maxillary sinus floor augmentation with Bio-Oss and autogenous bone from the iliac crest or the mandible in different ratios in minipigs.
Bilateral maxillary sinus floor augmentation was performed in 40 minipigs with: (A) 100% autogenous bone, (B) 75% autogenous bone and 25% Bio-Oss, (C) 50% autogenous bone and 50% Bio-Oss, (D) 25% autogenous bone and 75% Bio-Oss, and (E) 100% Bio-Oss. The autogenous bone graft was harvested from the iliac crest or the mandible and the graft composition was selected at random and placed concomitant with implant placement. Computed tomographies of the maxillary sinuses were obtained preoperatively, immediately postoperatively, and at euthanasia after 12 weeks. The volumetric changes of the graft were estimated using the Cavalieri principle and expressed as mean percentage with a 95% confidence interval (CI).
The mean volume of the graft was reduced by (A) 65% (95% CI: 60-70%), (B) 38% (95% CI: 35-41%), (C) 23% (95% CI: 21-25%), (D) 16% (95% CI: 12-21%), and (E) 6% (95% CI: 4-8%). The volumetric reduction was significantly influenced by the ratio of Bio-Oss and autogenous bone (P<0.001), but not by the origin of the autogenous bone graft (P=0.2).
The volume of autogenous bone grafts from the iliac crest and the mandible is reduced significantly after maxillary sinus floor augmentation in minipigs. The graft volume is better preserved after the addition of Bio-Oss and the volumetric reduction is significantly influenced by the ratio of Bio-Oss and autogenous bone. However, further studies are needed addressing the amount of new bone formation and bone-to-implant contact before the final conclusion can be made about the optimal ratio of Bio-Oss and autogenous bone.
本研究旨在了解小型猪上颌窦底骨增量中不同比例 Bio-Oss 与自体骨（来自髂嵴或下颌骨）后移植物的体积变化。
在 40 只小型猪双侧上颌窦底进行骨增量：（A）100%自体骨，（B）75%自体骨和 25%Bio-Oss，（C）50%自体骨和 50%Bio-Oss，（D）25%自体骨和 75%Bio-Oss，和（E）100%Bio-Oss。自体骨移植物取自髂嵴或下颌骨，随机选择移植物组成，并与种植体同时放置。术前、术后即刻和 12 周安乐死时获取上颌窦的计算机断层扫描。使用 Cavalieri 原理估计移植物的体积变化，并表示为平均百分比和 95%置信区间（CI）。
（A）组的移植物平均体积减少了 65%（95%CI：60-70%），（B）组减少了 38%（95%CI：35-41%），（C）组减少了 23%（95%CI：21-25%），（D）组减少了 16%（95%CI：12-21%），和（E）组减少了 6%（95%CI：4-8%）。Bio-Oss 和自体骨的比例对移植物的体积减少有显著影响（P<0.001），但自体骨移植物的来源无影响（P=0.2）。
小型猪上颌窦底骨增量后，来自髂嵴和下颌骨的自体骨移植物的体积显著减少。添加 Bio-Oss 后，移植物体积得到更好的保留，体积减少受 Bio-Oss 和自体骨比例的显著影响。然而，在得出关于 Bio-Oss 和自体骨最佳比例的最终结论之前，还需要进一步研究新骨形成的量和骨-种植体接触。
