Luo Y, McNamara B, Fennell M A, Teleis D C, May L, Rudy J, Watson A O, Uboh C E, Soma L R
University of Pennsylvania, School of Veterinary Medicine, New Bolton Center Campus, Philadelphia 19348, USA.
J Chromatogr B Biomed Sci Appl. 1998 Sep 4;714(2):269-76. doi: 10.1016/s0378-4347(98)00206-0.
A rapid and sensitive method for the extraction and quantification of penicillin-G and procaine in horse urine and plasma samples has been successfully developed. The method involves the use of solid-phase extraction (SPE) for penicillin-G, liquid-liquid extraction (LLE) for procaine, and high-performance liquid chromatography (HPLC) for the quantification of penicillin-G and procaine. The new method described here has been successfully applied in the pharmacokinetic studies of procaine, penicillin-G and procaine-penicillin-G administrations in the horse.
