Egawa K, Honda Y, Ono T, Kuroki M
Department of Dermatology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860, Japan.
Br J Dermatol. 1998 Aug;139(2):178-85. doi: 10.1046/j.1365-2133.1998.02352.x.
Carcinoembryonic antigen (CEA), which is a well-known marker for the normal sweat gland apparatus and its neoplasms in the skin, was recently demonstrated in sebaceous neoplasms. The aim of this study was to examine the expression of CEA and related antigens in the other cutaneous keratinous neoplasms and verruca vulgaris. Normal adult skin, squamous cell carcinoma (SCC), senile keratosis, Bowen's disease, basal cell carcinoma (BCC), seborrhoeic keratosis and verruca vulgaris were stained immunohistochemically with a panel of monoclonal and polyclonal antibodies that recognize different epitopes of CEA and related molecules. Localization of the antigens was compared with that of involucrin and proliferating cell nuclear antigen. The strongest expression of CEA-related antigens, other than non-specific cross-reacting antigen (NCA) -50/90, was seen in SCC and verruca vulgaris, while no detectable expression was seen in BCC. Senile keratosis, Bowen's disease and seborrhoeic keratosis showed the predominance of the CEA-related antigens over CEA weakly expressed. Strong expression of both CEA and NCA-50/90 was seen only in SCC. All the expressions were limited to the cells situated in the upper epidermal cell layers of the tumours, at the centre of tumour islands in SCC and along the pseudohorn cysts in seborrhoeic keratosis, where involucrin was coexpressed. We suggest that CEA and related antigens are not only markers for sweat gland differentiation in the skin, as currently accepted, but are also expressed in various cutaneous keratinous neoplasms and verruca vulgaris. The expression may correlate with the terminal differentiation of the tumour cells, the strong coexpression of CEA and NCA-50/90 may correlate with the malignant potential of the tumour types, and the mechanisms that control the expression of CEA and related antigens in the neoplasms may be similar to those operative in verruca vulgaris.
癌胚抗原（CEA）是一种在皮肤正常汗腺结构及其肿瘤中广为人知的标志物，最近在皮脂腺肿瘤中也有发现。本研究的目的是检测CEA及相关抗原在其他皮肤角质形成肿瘤和寻常疣中的表达。采用一组能识别CEA及相关分子不同表位的单克隆和多克隆抗体，对正常成人皮肤、鳞状细胞癌（SCC）、老年角化病、鲍温病、基底细胞癌（BCC）、脂溢性角化病和寻常疣进行免疫组织化学染色。将抗原的定位与内披蛋白和增殖细胞核抗原的定位进行比较。除非特异性交叉反应抗原（NCA）-50/90外，CEA相关抗原在SCC和寻常疣中表达最强，而在BCC中未检测到表达。老年角化病、鲍温病和脂溢性角化病显示CEA相关抗原的表达强于弱表达的CEA。仅在SCC中观察到CEA和NCA-50/90均强表达。所有表达均局限于肿瘤的上表皮细胞层中的细胞，在SCC的肿瘤岛中心以及脂溢性角化病的假角囊肿周围，这些部位同时表达内披蛋白。我们认为，CEA及相关抗原不仅是目前所公认的皮肤汗腺分化的标志物，而且也在各种皮肤角质形成肿瘤和寻常疣中表达。这种表达可能与肿瘤细胞的终末分化相关，CEA和NCA-50/90的强共表达可能与肿瘤类型的恶性潜能相关，并且控制肿瘤中CEA及相关抗原表达的机制可能与寻常疣中起作用的机制相似。
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