Scurry J, de Boer W G
Pathology. 1983 Oct;15(4):379-84. doi: 10.3109/00313028309085163.
Common benign skin abnormalities and related tumours were investigated for the presence of carcinoembryonic antigen (CEA) using immunohistological techniques in formalin-fixed tissue. CEA could be detected in all 10 squamous cell carcinomas examined, a finding which contrasted with those in earlier reports. CEA was not seen in normal skin but was present in the skins of 12-18-wk-old fetuses. Hence, CEA can be considered to be a true oncofetal antigen for ectodermal tissue. The antigen was not detected in seborrheic keratoses but was present in all 10 cases of keratoacanthoma. CEA was found in only one out of 10 basal cell carcinomas, the tumour being metatypical (basosquamous) in type. CEA was also observed in the minority of cases of solar keratosis and Bowen's disease. If the presence of CEA in proliferating epidermal tissue is associated with malignant transformation, both solar keratosis and Bowen's disease are indeed premalignant lesions whilst keratoacanthoma is the non-metastasizing variant of squamous cell carcinoma. Finally, the absence of CEA in basal cell carcinoma may help to explain its 'reluctance' to spread by metastasis.
运用免疫组织学技术，在福尔马林固定的组织中研究了常见的良性皮肤异常及相关肿瘤中癌胚抗原（CEA）的存在情况。在所检查的全部10例鳞状细胞癌中均能检测到CEA，这一发现与早期报告中的结果形成对比。正常皮肤中未见到CEA，但在12至18周龄胎儿的皮肤中存在。因此，CEA可被视为外胚层组织真正的癌胚抗原。在脂溢性角化病中未检测到该抗原，但在全部10例角化棘皮瘤中均有存在。在10例基底细胞癌中仅有1例发现CEA，该肿瘤为异型（基底鳞状）类型。在少数日光性角化病和鲍温病病例中也观察到了CEA。如果增殖性表皮组织中CEA的存在与恶性转化相关，那么日光性角化病和鲍温病确实是癌前病变，而角化棘皮瘤是鳞状细胞癌的非转移性变体。最后，基底细胞癌中CEA的缺失可能有助于解释其“不愿”通过转移扩散的现象。
