Bareicha I, Silva M R
Gen Pharmacol. 1976 Aug;7(2-3):103-6. doi: 10.1016/0306-3623(76)90043-4.
Clark's equation used in its inverted form (double reciprocal plots) was shown to be valid regarding the interaction of histamine with its receptors in the guinea-pig ileum. Burimamide, a typical H2-receptor antagonist potentiated the stimulating effect of small concentrations of histamine (10(-6) M) on the intestinal smooth muscle, probably, by blocking H2-receptors which may show the opposite effect. The calculated parameters of affinity (pKn) remained constant under different conditions. A linear correlation between length of the preparation and maximal contractions has been found.
克拉克方程以其倒数形式（双倒数图）用于豚鼠回肠中组胺与其受体的相互作用时，被证明是有效的。典型的H2受体拮抗剂布立马胺增强了低浓度组胺（10^(-6)M）对肠道平滑肌的刺激作用，这可能是通过阻断可能产生相反作用的H2受体来实现的。在不同条件下，计算得出的亲和力参数（pKn）保持不变。已发现标本长度与最大收缩之间存在线性相关性。
