Wainwright N J, Dawe R S, Ferguson J
Photodermatology Unit, Department of Dermatology, Ninewells Hospital and Medical School, Dundee DD1 9SY, U.K.
Br J Dermatol. 1998 Sep;139(3):410-4. doi: 10.1046/j.1365-2133.1998.02403.x.
Narrowband (311-313 nm) ultraviolet B phototherapy with the Philips TL-01 lamp is used increasingly in the treatment of psoriasis with little information available on the optimum irradiation regimen. We compared a high and a low incremental dose regimen in 20 patients with symmetrical chronic plaque psoriasis using a randomized half body study and thrice weekly exposures. Paired trunk, leg and arm plaques of psoriasis were scored blind prior to and at each treatment for scaling, erythema and induration. Patients were treated to clearance or minimal residual activity and followed up until relapse. The low increment regimen achieved a 10% reduction in the median cumulative dose to clearance (16,401 vs. 18,246 mJ/cm2) with one extra treatment in 50% of the patients. However, the duration of treatment (median 53.5 days) was identical for both regimens except for one patient because there were 50% fewer episodes of erythema requiring postponement of treatment with the low increment regimen. We now favour the low increment regimen for phototherapy in our psoriasis population.
采用飞利浦TL-01灯的窄谱（311 - 313纳米）紫外线B光疗法在银屑病治疗中的应用日益广泛，但关于最佳照射方案的信息却很少。我们采用随机半身研究及每周三次照射，对20例对称性慢性斑块状银屑病患者比较了高剂量递增方案和低剂量递增方案。在每次治疗前及治疗过程中，对成对的躯干、腿部和手臂银屑病斑块的鳞屑、红斑和硬结进行盲法评分。患者治疗至皮损清除或残留最小活性，并随访至复发。低剂量递增方案使清除皮损的中位累积剂量降低了10%（16,401 vs. 18,246 mJ/cm²），50%的患者多接受了一次治疗。然而，除一名患者外，两种方案的治疗持续时间（中位53.5天）相同，因为低剂量递增方案中因红斑而需要推迟治疗的次数减少了50%。我们现在倾向于在我们的银屑病患者群体中采用低剂量递增方案进行光疗。
