一项关于每周两次与每周三次窄谱中波紫外线光疗治疗慢性斑块状银屑病的随机、观察者盲法试验。

A randomized, observer-blinded trial of twice vs. three times weekly narrowband ultraviolet B phototherapy for chronic plaque psoriasis.

作者信息

Cameron H, Dawe R S, Yule S, Murphy J, Ibbotson S H, Ferguson J

机构信息

Photobiology Unit, Department of Dermatology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, U.K.

出版信息

Br J Dermatol. 2002 Nov;147(5):973-8. doi: 10.1046/j.1365-2133.2002.04996.x.

DOI:10.1046/j.1365-2133.2002.04996.x

PMID:12410709

Abstract

BACKGROUND

The optimum treatment frequency for narrowband (TL-01) ultraviolet B (NB-UVB) in psoriasis is not yet known. We have previously found three times weekly to be preferable to five times weekly treatment in our population.

OBJECTIVES

To compare twice weekly with three times weekly NB-UVB phototherapy in chronic plaque psoriasis.

METHODS

In an observer-blinded, randomized comparison, patients with chronic plaque psoriasis referred from dermatology out-patient clinics in Tayside for NB-UVB phototherapy received either twice weekly (Monday and Friday) or three times weekly (Monday, Wednesday and Friday) whole-body NB-UVB phototherapy following our standard departmental treatment protocol. Treatment was continued to clearance or until the fourth treatment after minimal residual activity (MRA) was first documented. Number of days in treatment, number of treatments, total dose and time to relapse were recorded.

RESULTS

In total, 113 patients were recruited, skin phototypes I-III: 58 in the twice weekly and 55 in the three times weekly group. Forty patients in the twice weekly group reached clearance/MRA, as did 44 in the three times weekly group. It took 1.5 (95% confidence interval 1.3-1.7) times longer to reach clearance/MRA with twice weekly therapy, a geometric mean of 88 vs. 58 days (P < 0.0001). Small differences in numbers of treatments and total dose to reach clearance tended to favour three times weekly therapy, but these were not significant.

CONCLUSIONS

Three times weekly NB-UVB clears psoriasis significantly faster than twice weekly treatment, and therefore is preferable for most patients.

摘要

背景

窄谱（TL - 01）紫外线B（NB - UVB）治疗银屑病的最佳治疗频率尚不清楚。我们之前发现在我们的研究人群中，每周三次治疗比每周五次治疗更可取。

目的

比较每周两次与每周三次NB - UVB光疗治疗慢性斑块状银屑病的效果。

方法

在一项观察者盲法、随机对照研究中，从泰赛德地区皮肤科门诊转诊来接受NB - UVB光疗的慢性斑块状银屑病患者，按照我们科室的标准治疗方案，分别接受每周两次（周一和周五）或每周三次（周一、周三和周五）的全身NB - UVB光疗。治疗持续至皮损清除或记录到最小残留活动度（MRA）后第四次治疗。记录治疗天数、治疗次数、总剂量及复发时间。

结果

共招募113例患者，皮肤光类型为I - III型：每周两次治疗组58例，每周三次治疗组55例。每周两次治疗组40例患者达到皮损清除/MRA，每周三次治疗组为44例。每周两次治疗达到清除/MRA所需时间长1.5倍（95%置信区间1.3 - 1.7），几何平均数分别为88天和58天（P < 0.0001）。达到清除时治疗次数和总剂量的微小差异倾向于支持每周三次治疗组，但差异无统计学意义。