青少年落叶型天疱疮

Juvenile pemphigus foliaceus.

作者信息

Mehravaran M, Morvay M, Molnár K, Oláh J, Korom I, Husz S, Dobozy A

机构信息

Department of Dermatology, Albert Szent-Györgyi Medical University, H-6701 Szeged, Korányi fasor 6, PO Box 480, Szeged, Hungary.

出版信息

Br J Dermatol. 1998 Sep;139(3):496-9. doi: 10.1046/j.1365-2133.1998.02417.x.

DOI:10.1046/j.1365-2133.1998.02417.x

PMID:9767298

Abstract

A 7-year-old girl with generalized erythematous, scaling plaques and vesiculobullous lesions on the extremities was diagnosed as having pemphigus foliaceus. Lesional direct immunofluorescence revealed intercellular IgG, IgA and C3 deposition. The patient's serum gave positive reactions against one epitope of desmoglein 3 and the epitope of desmoglein 1 in enzyme-linked immunosorbent assays, but the blood sample for indirect immunofluorescence did not display any circulating antibodies. The patient was successfully treated systemically with prednisolone and dapsone. Currently, she is taking dapsone, 12.5 mg daily. She has been free of lesions for the last 3 years.

摘要

一名7岁女童，四肢出现广泛性红斑、鳞屑性斑块及水疱大疱性皮损，被诊断为落叶型天疱疮。皮损处直接免疫荧光显示细胞间IgG、IgA和C3沉积。在酶联免疫吸附试验中，患者血清对桥粒芯糖蛋白3的一个表位和桥粒芯糖蛋白1的表位呈阳性反应，但间接免疫荧光血样未显示任何循环抗体。患者接受泼尼松龙和氨苯砜全身治疗成功。目前，她每天服用12.5mg氨苯砜。在过去3年里她一直没有皮损。