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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Gen Pharmacol. 1976 Sep;7(4):259-62. doi: 10.1016/0306-3623(76)90085-9.

The effects of a number of centrally-acting compoinds were tested on the levels of GABA and glutamate and on the formation of GABA from glutamate in rat brain. 2. Pargyline and desipramine increased the brain concentration of GABA but were without effect on GABA production. 3. Imidazoleacetic acid increased GABA levels, decreased glutamate levels but did not alter GABA production, whereas gamma-hydroxybutyric acid had an effect only on GABA formation. 4. Isonicotinc acid hydrazine caused a marked decrease in the formation of GABA from glutamate. 5. Chlorpromazine, diphenylhydantoin, bicucculine, and L-DOPA had no effect on any of the biochemical parameters measured. 6. The central effects of these drugs are discussed in relation to the above findings.

测试了多种中枢作用化合物对大鼠脑中γ-氨基丁酸（GABA）和谷氨酸水平以及谷氨酸生成GABA的影响。2. 帕吉林和地昔帕明提高了脑内GABA的浓度，但对GABA的生成没有影响。3. 咪唑乙酸提高了GABA水平，降低了谷氨酸水平，但未改变GABA的生成，而γ-羟基丁酸仅对GABA的生成有影响。4. 异烟肼导致谷氨酸生成GABA的过程显著减少。5. 氯丙嗪、苯妥英、荷包牡丹碱和左旋多巴对所测的任何生化参数均无影响。6. 根据上述研究结果对这些药物的中枢作用进行了讨论。

Gen Pharmacol. 1976 Sep;7(4):259-62. doi: 10.1016/0306-3623(76)90085-9.

The effects of a number of centrally-acting compoinds were tested on the levels of GABA and glutamate and on the formation of GABA from glutamate in rat brain. 2. Pargyline and desipramine increased the brain concentration of GABA but were without effect on GABA production. 3. Imidazoleacetic acid increased GABA levels, decreased glutamate levels but did not alter GABA production, whereas gamma-hydroxybutyric acid had an effect only on GABA formation. 4. Isonicotinc acid hydrazine caused a marked decrease in the formation of GABA from glutamate. 5. Chlorpromazine, diphenylhydantoin, bicucculine, and L-DOPA had no effect on any of the biochemical parameters measured. 6. The central effects of these drugs are discussed in relation to the above findings.

测试了多种中枢作用化合物对大鼠脑中γ-氨基丁酸（GABA）和谷氨酸水平以及谷氨酸生成GABA的影响。2. 帕吉林和地昔帕明提高了脑内GABA的浓度，但对GABA的生成没有影响。3. 咪唑乙酸提高了GABA水平，降低了谷氨酸水平，但未改变GABA的生成，而γ-羟基丁酸仅对GABA的生成有影响。4. 异烟肼导致谷氨酸生成GABA的过程显著减少。5. 氯丙嗪、苯妥英、荷包牡丹碱和左旋多巴对所测的任何生化参数均无影响。6. 根据上述研究结果对这些药物的中枢作用进行了讨论。