绵羊肠道对苯胺的体外代谢
In vitro metabolism of aniline by sheep intestine.
作者信息
Turner J C, Green R S, Kelly W J
出版信息
Gen Pharmacol. 1976 Sep;7(4):289-91. doi: 10.1016/0306-3623(76)90091-4.
PMID:976743
Abstract
- The major metabolite after incubating aniline with sheep intestine was acetanilide. 2. Other metabolites detected in smaller amounts were 2-aminophenol, 4-aminophenol, 2-acetamidophenol and 4-acetamidophenol. 3. The rumen, abomasum duodenum, jejunum, ileum and colon were all able to acetylate aniline. 4. 4-Aminophenol, 4-aminobenzoic acid, 4-anisidine and 4-nitroaniline were also acetylated.
摘要
- 将苯胺与羊肠一起孵育后的主要代谢产物是乙酰苯胺。2. 检测到的其他少量代谢产物有2-氨基苯酚、4-氨基苯酚、2-乙酰氨基苯酚和4-乙酰氨基苯酚。3. 瘤胃、皱胃、十二指肠、空肠、回肠和结肠均能够使苯胺乙酰化。4. 4-氨基苯酚、4-氨基苯甲酸、4-甲氧基苯胺和4-硝基苯胺也被乙酰化。
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