Fujita J, Obayashi Y, Yamadori I, Ohtsuki Y, Miyawaki H, Hojo S, Furukawa Y, Takahara J
First Department of Internal Medicine, Kagawa Medical University, Kagawa, Japan.
Respirology. 1998 Sep;3(3):211-4. doi: 10.1111/j.1440-1843.1998.tb00124.x.
A 53-year-old Japanese female, who had been suffering from idiopathic pulmonary fibrosis (IPF) for 3 years, was admitted with dyspnoea. The important laboratory finding on admission was a serum CA19-9 level of 649 U/mL. Despite steroid treatment for IPF, her respiratory condition gradually deteriorated with the increase of serum CA19-9 level up to 3020 U/mL and she died of respiratory failure. Immunohistochemistry showed the positive stain of CA19-9 in bronchoepithelial cells. We also reviewed the Index Medics and picked up the cases who had elevation of CA19-9 more than 1000 U/mL, and six patients were listed. Five of these six patients died within 6 months, therefore the marked elevation of CA19-9 seemed to be a bad prognostic factor in patients with pulmonary fibrosis.
一名53岁的日本女性，患有特发性肺纤维化（IPF）3年，因呼吸困难入院。入院时重要的实验室检查结果是血清CA19-9水平为649 U/mL。尽管接受了针对IPF的类固醇治疗，但她的呼吸状况随着血清CA19-9水平升高至3020 U/mL而逐渐恶化，最终死于呼吸衰竭。免疫组织化学显示支气管上皮细胞中CA19-9呈阳性染色。我们还查阅了医学索引并挑选出CA19-9升高超过1000 U/mL的病例，共列出6例患者。这6例患者中有5例在6个月内死亡，因此CA19-9的显著升高似乎是肺纤维化患者的不良预后因素。
