Crow S, Meller W, Praus B, Raatz S, Mitchell J
Department of Psychiatry, University of Minnesota Hospital and Clinic, Minneapolis 55455, USA.
Pharmacol Biochem Behav. 1998 Nov;61(3):317-21. doi: 10.1016/s0091-3057(98)00127-0.
The alpha2-adrenergic system is involved in the regulation of food intake in animals but its effects on feeding in humans are unknown. We hypothesized that clonidine administration would stimulate food intake in healthy human subjects. Ten men and 4 women, all physically and psychiatrically healthy, received clonidine 3 microg/kg or placebo, orally, in blinded, balanced, randomized order. Consumption of a liquid test meal was measured; also, serum growth hormone levels were used as a secondary measure of clonidine effects. Visual analog scale ratings of hunger, satiety, and sedation were obtained before, during, and after the test meal. A subset of five subjects also received 1.5 microg/kg clonidine, in addition to the two trials described above. Test meal consumption was greater following placebo than following clonidine. Sedation ratings were substantially higher at all time points after clonidine and correlated with meal consumption (correlation coefficient r = -0.584; p = 0.028). Hunger and satiety ratings did not differ. The 1.5 microg/kg dose did not provide different effects on feeding from that seen with placebo. Contrary to our hypothesis, clonidine did not stimulate food intake in humans. Sedation associated with clonidine administration may have suppressed any effects on feeding.
α2-肾上腺素能系统参与动物的食物摄入量调节，但其对人类进食的影响尚不清楚。我们假设服用可乐定可刺激健康人类受试者的食物摄入。10名男性和4名女性，均身体健康且无精神疾病，以盲法、平衡、随机的顺序口服3μg/kg可乐定或安慰剂。测量了液体试验餐的摄入量；此外，血清生长激素水平用作可乐定效应的次要测量指标。在试验餐之前、期间和之后获得饥饿、饱腹感和镇静的视觉模拟量表评分。除上述两项试验外，五名受试者的一个子集还接受了1.5μg/kg可乐定。服用安慰剂后的试验餐摄入量高于服用可乐定后。服用可乐定后所有时间点的镇静评分均显著更高，且与餐量摄入量相关（相关系数r = -0.584；p = 0.028）。饥饿和饱腹感评分无差异。1.5μg/kg剂量对进食的影响与安慰剂所见无异。与我们的假设相反，可乐定并未刺激人类的食物摄入。与服用可乐定相关的镇静作用可能抑制了对进食的任何影响。
