Lucotte G, Mercier G
Neurology Department, Maison Blanche Hospital, Rheims, France.
J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Oct 1;19(2):174-7. doi: 10.1097/00042560-199810010-00011.
The chemokine receptor CCR5 constitutes the major coreceptor for the macrophage-tropic strains of HIV-1. A mutant allele of the CCR5 gene called delta32 was shown to provide strong resistance to homozygotes against infection by HIV. The frequency of the delta32 allele was investigated in 2522 noninfected unrelated individuals from 16 different European populations. The delta32 allele was found in all populations studied, with a mean frequency of about 9.1%. A north-to-south gradient correlating latitude with delta32 allelic frequencies was found (r = 0.726), with highest allele frequencies in Denmark and Northern France, and the lowest allele frequencies in Corsica.
趋化因子受体CCR5是HIV-1巨噬细胞嗜性毒株的主要共受体。CCR5基因的一个名为delta32的突变等位基因被证明能为纯合子提供强大的抗HIV感染能力。在来自16个不同欧洲人群的2522名未感染的无关个体中，对delta32等位基因的频率进行了调查。在所研究的所有人群中均发现了delta32等位基因，平均频率约为9.1%。发现了一个将纬度与delta32等位基因频率相关联的由北向南的梯度（r = 0.726），丹麦和法国北部的等位基因频率最高，科西嘉岛的等位基因频率最低。
