Peschke P, Hahn E W, Wenz F, Lohr F, Braunschweig F, Wolber G, Zuna I, Wannenmacher M
Department of Radiation Oncology, German Cancer Research Center, Heidelberg.
Radiat Res. 1998 Oct;150(4):423-30.
To better understand the relationship of the growth characteristics of tumor tissues and their response to ionizing radiation alone and in combination with local tumor hyperthermia, we compared three different tumor sublines of the Dunning rat prostate carcinoma R3327. This report includes results obtained with the anaplastic AT1 subline (volume doubling time 5.2 days), the moderately differentiated mucin-secreting HI subline (volume doubling time about 9 days) and the well-differentiated, hormone-dependent H subline (volume doubling time about 17 days). The effects of single doses of photons (10 to 40 Gy) with and without local tumor hyperthermia (35 min immersion at 43.5 degrees C) were quantified by growth delay. The time to reach five times the volume at the time of treatment after 30 Gy alone was found to be 56.0, 134.9 and 184.0 days for the R3327-AT1, HI and H tumors, respectively. The R3327-H tumor was more radiosensitive than the AT1 or HI subline. Five of nine R3327-H tumors were controlled locally with a single dose of photons (40 Gy). Local tumor hyperthermia alone induced growth delay in both differentiated tumors, while the anaplastic tumor subline did not respond. Combined treatment modalities with heat applied directly after irradiation revealed isoeffective thermal enhancement ratios for 30 Gy which decreased from 1.59 for the AT1 tumor and 1.42 for the HI tumor to 1.23 in the well-differentiated subline R3327-H.
为了更好地理解肿瘤组织生长特性与其对单独电离辐射以及与局部肿瘤热疗联合治疗的反应之间的关系，我们比较了Dunning大鼠前列腺癌R3327的三种不同肿瘤亚系。本报告包括间变性AT1亚系（体积倍增时间5.2天）、中度分化的黏液分泌型HI亚系（体积倍增时间约9天）和高分化、激素依赖性H亚系（体积倍增时间约17天）的研究结果。通过生长延迟来量化单剂量光子（10至40 Gy）在有和没有局部肿瘤热疗（43.5摄氏度下浸泡35分钟）情况下的效果。单独给予30 Gy照射后，R3327-AT1、HI和H肿瘤达到治疗时体积五倍的时间分别为56.0、134.9和184.0天。R3327-H肿瘤比AT1或HI亚系对辐射更敏感。9个R3327-H肿瘤中有5个通过单剂量光子（40 Gy）实现了局部控制。单独的局部肿瘤热疗在两种分化型肿瘤中均诱导了生长延迟，而间变性肿瘤亚系无反应。照射后直接加热的联合治疗方式显示，30 Gy的等效热增强比从AT1肿瘤的1.59和HI肿瘤的1.42降至高分化亚系R3327-H的1.23。
