Bonkhoff H, Remberger K
Institute of Pathology, University of the Saarland, Homburg-Saar, Germany.
Virchows Arch. 1998 Sep;433(3):195-202. doi: 10.1007/s004280050236.
Benign prostatic hyperplasia (BPH) and prostate cancer are multifactorial disease processes, involving a growing number of biochemical, genetic and epigenetic factors. Their pathogenesis, however, remains poorly understood. The present review examines current morphogenetic concepts of normal and abnormal growth in the human prostate. This includes the role of basal cells in organogenesis and cancerogenesis, the impact of cell-matrix interactions, and the importance of cellular heterogeneity in tumour progression and hormone-insensitive growth. Knowledge of morphogenesis and morphology is required in any scientific approach to BPH and prostate cancer.
良性前列腺增生（BPH）和前列腺癌是多因素疾病过程，涉及越来越多的生化、遗传和表观遗传因素。然而，它们的发病机制仍知之甚少。本综述探讨了人类前列腺正常和异常生长的当前形态发生概念。这包括基底细胞在器官发生和肿瘤发生中的作用、细胞-基质相互作用的影响，以及细胞异质性在肿瘤进展和激素不敏感生长中的重要性。在任何研究BPH和前列腺癌的科学方法中，都需要了解形态发生和形态学知识。
