Department of Cell Biology, Institute of Biology-UNICAMP, CP 6109, Campinas, São Paulo, Brazil.
Int J Exp Pathol. 2010 Apr;91(2):132-43. doi: 10.1111/j.1365-2613.2009.00685.x. Epub 2009 Dec 22.
The female organs, which are regulated by steroid hormones, are targets of studies especially those related to senescence. However, although the female prostate is an organ influenced by hormones and susceptible to lesions, there is still little information about its histopathology. Thus, given the morphophysiological similarity between the prostate in women and female gerbils, the present study aimed to identify the spontaneous histopathological changes in this rodent to provide contributions to the understanding of lesions that also affect the human female prostate. The structural, ultrastructural, immunohistochemical, morphometric-stereological and serological aspects, as well as the quantification of the incidence, multiplicity and percentage of acini affected by different lesions were analyzed. Benign prostate lesions including hyperplasia, prostatitis, microcalculi and calculi; preneoplastic lesions like dysplasias; premalignant lesions, such as high grade prostatic intraepithelial neoplasia as well as malignant ones, specifically adenocarcinoma, were identified in the adult gland, but they were intensified during senescence, which is possibly due to the imbalance among steroid hormone levels. Although clinical attention focuses on other urogenital organs, the real condition of the histopathological injuries in the human female prostate should be considered. A serious preventive work regarding the female prostate could be applied in the gynaecological context in order to monitor the gland and avoid possible disturbances to women's health and consequently provide better quality of life.
女性生殖器官受类固醇激素调节，是研究的对象，特别是与衰老相关的研究。然而，尽管女性前列腺是一种受激素影响且易发生病变的器官，但关于其组织病理学的信息仍然很少。因此，鉴于女性和雌性沙鼠前列腺在形态生理学上的相似性，本研究旨在确定该啮齿动物的自发性组织病理学变化，为理解也影响人类女性前列腺的病变提供贡献。分析了结构、超微结构、免疫组织化学、形态计量学-体视学以及血清学方面，以及不同病变对腺泡的发生率、多发性和百分比的定量。良性前列腺病变包括增生、前列腺炎、微结石和结石；癌前病变，如发育不良；恶性病变，如高级别前列腺上皮内瘤变，以及腺癌，在成年腺中都有发现，但在衰老过程中会加剧，这可能是由于类固醇激素水平失衡所致。尽管临床注意力集中在其他泌尿生殖器官上，但应该考虑到人类女性前列腺的组织病理学损伤的真实情况。可以在妇科背景下开展针对女性前列腺的严重预防工作，以监测该腺体，避免对女性健康造成可能的干扰，从而提供更好的生活质量。
