Frank T L, Adisesh A, Pickering A C, Morrison J F, Wright T, Francis H, Fletcher A, Frank P I, Hannaford P
North West Lung Centre, Wythenshawe Hospital, and Royal College of General Practitioners Manchester Research Unit, Parkway House, Manchester, UK.
Am J Respir Crit Care Med. 1998 Oct;158(4):1032-6. doi: 10.1164/ajrccm.158.4.9707143.
The purpose of the study was to determine if exhaled nitric oxide levels in children varied according to their asthmatic and atopic status. Exhaled nitric oxide was measured in a sample of 93 children attending the North West Lung Centre, Manchester, United Kingdom, for the clinical evaluation of a respiratory questionnaire being developed as a screening tool in general practice. The clinical assessment included full lung function, skin prick testing, and exercise challenge. Children were said to be asthmatic either by consensus decision of three independent consultant pediatricians, who reviewed all the clinical results except the nitric oxide measurements, or by positive exercise test. Atopic asthmatic children had higher geometric mean exhaled nitric oxide levels (consensus decision, 12.5 ppb [parts per billion] 95% CI, 8.3 to 18. 8; positive exercise test, 12.2 ppb 95% CI, 7.6 to 19.7) than did nonatopic asthmatic children (3.2 ppb 95% CI, 2.3 to 4.6; 3.2 ppb 95% CI, 2.0 to 5.0), atopic nonasthmatic children (3.8 ppb 95% CI, 2. 7 to 5.5; 5.7 ppb 95% CI, 4.1 to 8.0), or nonatopic nonasthmatic children (3.4 ppb 95% CI, 2.8 to 4.1; 3.5 ppb 95% CI, 3.0 to 4.1). Thus, exhaled nitric oxide was raised in atopic asthmatics but not in nonatopic asthmatics, and these nonatopic asthmatics had levels of exhaled nitric oxide similar to those of the nonasthmatics whether atopic or not.
该研究的目的是确定儿童呼出一氧化氮水平是否因其哮喘和特应性状态而异。在英国曼彻斯特西北肺中心就诊的93名儿童样本中测量了呼出一氧化氮，这些儿童参与了一项正在开发的呼吸问卷的临床评估，该问卷将作为全科医疗中的筛查工具。临床评估包括全肺功能、皮肤点刺试验和运动激发试验。儿童被判定为哮喘患者，要么是由三位独立的儿科顾问医生共同做出的决定（他们审查了除一氧化氮测量结果之外的所有临床结果），要么是运动试验呈阳性。特应性哮喘儿童的呼出一氧化氮几何平均水平（共同决定，12.5 ppb[十亿分之一]，95%可信区间，8.3至18.8；运动试验阳性，12.2 ppb，95%可信区间，7.6至19.7）高于非特应性哮喘儿童（3.2 ppb，95%可信区间，2.3至4.6；3.2 ppb，95%可信区间，2.0至5.0）、特应性非哮喘儿童（3.8 ppb，95%可信区间，2.7至5.5；5.7 ppb，95%可信区间，4.1至8.0）或非特应性非哮喘儿童（3.4 ppb，95%可信区间，2.8至4.1；3.5 ppb，95%可信区间，3.0至4.1）。因此，特应性哮喘患者呼出一氧化氮水平升高，而非特应性哮喘患者则不然，并且这些非特应性哮喘患者的呼出一氧化氮水平与非哮喘患者（无论是否为特应性）相似。
