重离子辐照诱导B6C3F1小鼠卵巢肿瘤
Induction of ovarian tumors by heavy ion irradiation in B6C3F1 mice.
作者信息
Watanabe H, Ogiu T, Nishizaki M, Fujimoto N, Kido S, Ishimura Y, Shiraki K, Kuramoto K, Hirata S, Shoji S, Katoh O
机构信息
Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami-ku, Hiroshima 734-8553, Japan.
出版信息
Oncol Rep. 1998 Nov-Dec;5(6):1377-80. doi: 10.3892/or.5.6.1377.
Six-week-old B6C3F1 mice were exposed to 0.439 Gy heavy ion irradiation as a 290 MeV/u carbon-ion beam (LET 10 keV/micron) at 2 cm from the upper proximal point of a spread Bragg beam and autopsied 13.5 months after the irradiation. In males total tumor incidences, mainly liver tumors, were 37.0% in irradiated group and 25.0% in control (P>0.05). In females the total tumor incidences were 32.3%, mainly ovarian tumors, in the irradiated group and 0% in the controls. These results indicate that heavy ion irradiation induces ovarian tumors in females but does not target any organ in males.
六周龄的B6C3F1小鼠暴露于0.439 Gy的重离子辐射下，该辐射为290 MeV/u的碳离子束（线能量转移为10 keV/微米），距离扩展布拉格峰的上近端点2 cm，在辐射后13.5个月进行解剖。在雄性小鼠中，主要为肝脏肿瘤的总肿瘤发生率在辐照组中为37.0%，在对照组中为25.0%（P>0.05）。在雌性小鼠中，辐照组的总肿瘤发生率为32.3%，主要为卵巢肿瘤，而对照组为0%。这些结果表明，重离子辐射可诱导雌性小鼠发生卵巢肿瘤，但对雄性小鼠的任何器官均无靶向作用。
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