Watanabe H, Ogiu T, Nishizaki M, Fujimoto N, Kido S, Ishimura Y, Shiraki K, Kuramoto K, Hirata S, Shoji S, Katoh O
Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami-ku, Hiroshima 734-8553, Japan.
Oncol Rep. 1998 Nov-Dec;5(6):1377-80. doi: 10.3892/or.5.6.1377.
Six-week-old B6C3F1 mice were exposed to 0.439 Gy heavy ion irradiation as a 290 MeV/u carbon-ion beam (LET 10 keV/micron) at 2 cm from the upper proximal point of a spread Bragg beam and autopsied 13.5 months after the irradiation. In males total tumor incidences, mainly liver tumors, were 37.0% in irradiated group and 25.0% in control (P>0.05). In females the total tumor incidences were 32.3%, mainly ovarian tumors, in the irradiated group and 0% in the controls. These results indicate that heavy ion irradiation induces ovarian tumors in females but does not target any organ in males.
六周龄的B6C3F1小鼠暴露于0.439 Gy的重离子辐射下，该辐射为290 MeV/u的碳离子束（线能量转移为10 keV/微米），距离扩展布拉格峰的上近端点2 cm，在辐射后13.5个月进行解剖。在雄性小鼠中，主要为肝脏肿瘤的总肿瘤发生率在辐照组中为37.0%，在对照组中为25.0%（P>0.05）。在雌性小鼠中，辐照组的总肿瘤发生率为32.3%，主要为卵巢肿瘤，而对照组为0%。这些结果表明，重离子辐射可诱导雌性小鼠发生卵巢肿瘤，但对雄性小鼠的任何器官均无靶向作用。
