Kitamura M, Toi M, Arai K, Iwasaki Y, Suzuki H, Matsuo K
Department of Surgery, Tokyo Metropolitan Komagome Hospital, Bunkyo-ku, Tokyo 113-8677, Japan.
Oncol Rep. 1998 Nov-Dec;5(6):1419-24. doi: 10.3892/or.5.6.1419.
VEGF (vascular endothelial growth factor) is known to play crucial roles in tumor angiogenesis. In 281 gastric cancer patients, aberrant increase of VEGF level was observed in 36 patients (12.8%). In 14 recurrent patients, 8 showed an increase of VEGF. The serum VEGF levels of stage IV cancer were significantly higher than those of stage I. The serum levels of recurrent patients were significantly higher than those of stage I, II and III. VEGF levels of patients with serosal invasion were significantly higher than those of patients without serosal invasion. In depth of invasion (t-factor), VEGF levels of t4 cancer were significantly higher than those of t1-t3. In venous infiltration of tumors, VEGF levels of v3 were significantly higher than v0 and v1. There was no significant difference with respect to H-factor and P-factor status. In eleven recurrent or advanced gastric cancer patients, serum VEGF was sequentially examined between pre- and post-chemotherapy. All of them showed a decrease of serum VEGF concentration after partial response by chemotherapy. The patients who had progressive disease after chemotherapy showed an increase of VEGF levels. Serum VEGF levels were closely related to the extent of gastric cancer and the response of chemotherapy.
血管内皮生长因子（VEGF）在肿瘤血管生成中发挥着关键作用。在281例胃癌患者中，36例（12.8%）观察到VEGF水平异常升高。在14例复发患者中，8例VEGF升高。IV期癌症患者的血清VEGF水平显著高于I期患者。复发患者的血清水平显著高于I、II和III期患者。有浆膜侵犯患者的VEGF水平显著高于无浆膜侵犯患者。在浸润深度（t因子）方面，t4期癌症患者的VEGF水平显著高于t1 - t3期。在肿瘤静脉浸润方面，v3期的VEGF水平显著高于v0和v1期。在H因子和P因子状态方面无显著差异。在11例复发或晚期胃癌患者中，化疗前后对血清VEGF进行了连续检测。化疗部分缓解后，所有患者血清VEGF浓度均下降。化疗后病情进展的患者VEGF水平升高。血清VEGF水平与胃癌的范围及化疗反应密切相关。
