胃癌患者血浆中血管内皮生长因子（VEGF）和碱性成纤维细胞生长因子（bFGF）的浓度。

Plasma concentrations of VEGF and bFGF in patients with gastric carcinoma.

作者信息

Yoshikawa T, Tsuburaya A, Kobayashi O, Sairenji M, Motohashi H, Yanoma S, Noguchi Y

机构信息

The Third Department of Surgery, Kanagawa Cancer Center, 1-1-2 Nakao, Asahi-Ku, Yokohama, Japan.

出版信息

Cancer Lett. 2000 May 29;153(1-2):7-12. doi: 10.1016/s0304-3835(99)00426-7.

DOI:10.1016/s0304-3835(99)00426-7

PMID:10779624

Abstract

We examined plasma levels of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in 54 patients with gastric carcinoma. Postoperative survival was significantly poorer in patients with plasma VEGF levels more than 10.0 pg/ml at the time of surgery. By an univariate analysis of the factors affecting survival, serosal invasion, lymph node metastasis, peritoneal dissemination, lymphatic vessel invasion, curability, and VEGF proteins were significant. By a multivariate analysis only VEGF levels and curability remained significant. Patients with recurrent disease, including liver metastasis, had significantly higher plasma VEGF concentrations than those with resectable primary tumors. VEGF, not bFGF, may serve as an independent prognosticator and a sensitive indicator for liver recurrence in patients with gastric carcinoma.

摘要

我们检测了54例胃癌患者血浆中血管内皮生长因子（VEGF）和碱性成纤维细胞生长因子（bFGF）的水平。手术时血浆VEGF水平超过10.0 pg/ml的患者术后生存率明显较差。通过对影响生存的因素进行单因素分析，浆膜侵犯、淋巴结转移、腹膜播散、淋巴管侵犯、可治愈性和VEGF蛋白具有显著性。通过多因素分析，只有VEGF水平和可治愈性仍然具有显著性。包括肝转移在内的复发疾病患者血浆VEGF浓度明显高于可切除原发性肿瘤患者。VEGF而非bFGF可能是胃癌患者肝转移的独立预后指标和敏感指标。